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Etofenamate

Etofenamate Property

Melting point 25°C
Boiling point bp.001 130-135°
Density 1.2866 (estimate)
refractive index nD25 1.564
storage temp. Sealed in dry,2-8°C
solubility Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate.
form Oil
pka 14.32±0.10(Predicted)
color Light yellow to yellow
Stability Light Sensitive
FDA UNII KZF0XM66JC
ATC code M02AA06
UNSPSC Code 41116107
NACRES NA.24

Safety

RIDADR :UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all
Toxicity :LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi)

NFPA 704:

Hazard and Precautionary Statements (GHS)

Etofenamate Chemical Properties,Usage,Production

Chemical Properties Light Yellow Oil
Originator Rheumon,Troponwerke,W. Germany,1977
Uses As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.
Definition ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.
Manufacturing Process 16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)- anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to 110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added. The reaction mixture is then heated to boiling for 2 hours. The precipitated potassium chloride is filtered off and the solvent is removed by evaporation. The residue is separated over a column with 400 g of silica gel (particle size 0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3- trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale yellow oil which does not crystallize and cannot be distilled.
Therapeutic Function Antiinflammatory

Etofenamate Preparation Products And Raw materials

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Etofenamate Spectrum

30544-47-9, EtofenamateRelated Search:

Pharmaceuticals
Intermediates & Fine Chemicals
Aromatics
Amines
Inhibitors
抑制剂
药靶配体
化工原料
神经系统用药
小分子抑制剂，天然产物
小分子抑制剂
依托芬那酯,10 MM DMSO 溶液
依托非那酯
依托芬那酯峰鉴别 EP标准品
依托芬那酯 EP标准品
依托芬那酯, >98%
ETOFENAMATE油状
氟灭酸酯
氟灭酸酯/依托芬那酯
依托芬那酯
2[[3-(三氟甲基)苯基]氨基]-2-(羟乙氧基)乙基苯甲酸酯
2-(2-羟基乙氧基)乙基 2-[3-(三氟甲基)苯胺基]苯甲酸酯
30544-47-9
Etofenamate, 10 mM in DMSO
Etofenate
Etofenamate USP/EP/BP
Benzoic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 2-(2-hydroxyethoxy)ethyl ester
Etofenamate for peak identification CRS
Etofenamate CRS
CS-1431
Etofenamate, >=98%
TVX-485
TV-485
EtofenaMate,TV-485
2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoroMethyl)phenyl)aMino)benzoate
TrauMon Gel
ReuMon
Bayrogel
2-[[3-(TrifluoroMethyl)phenyl]aMino]benzoic Acid 2-(2-Hydroxyethoxy)ethyl Ester
2-(2-Hydroxyethoxy)ethyl FufenaMate
Etofenamate
Rheumon
Ethofenamate
2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
n-(alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid 2-(2-hydroxyethoxy)
Benzoic acid, 2[[3-(trifluoromethyl)phenyl]amino]-2-(hydroxyethoxy)ethyl ester
2-(2-hydroxyethoxy)ethyl-n-(alpha,alpha,alpha-trifluoro-m-tolyl)anthrani late
2-(2-hydroxyaethoxy)aethylester der flutenaminsaeure
EtofenamateEtofenamate