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METHYLENE BLUE

CAS No.122965-43-9
Chemical Name:METHYLENE BLUE
CBNumber:CB6748861
Molecular Formula:C16H20ClN3OS
Formula Weight:337.87
MOL File:122965-43-9.mol

METHYLENE BLUE Property

Melting point 190 °C
storage temp. 2-8°C
solubility H2O: soluble4mg/4ml
Colour Index 52015
form Fine Crystalline Powder
color Green
Water Solubility Soluble in water, alcohol, acetic acid, glycerol and chloroform. Insoluble in ether.
λmax 661 nm
Merck 14,6060
BRN 3599847
FDA UNII T42P99266K
UNSPSC Code 41116107
NACRES NA.52

Safety

Hazard Codes :Xn
Risk Statements :22
Safety Statements :26-39-61
RIDADR :UN 2811 6.1/PG 3
WGK Germany :3
RTECS :SO5600000
TSCA :Yes
HS Code :32041300

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

METHYLENE BLUE Price More Price(15)

Brand: Sigma-Aldrich(India)
Product number: M9140
Product name : Methylene blue
Purity: certified by the Biological Stain Commission
Packaging: 25G
Price: ₹4084.8
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M9140
Product name : Methylene blue
Purity: certified by the Biological Stain Commission
Packaging: 100G
Price: ₹12320
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M4159
Product name : Methylene Blue hydrate
Purity: suitable for nucleic acid staining, BioReagent
Packaging: 25G
Price: ₹5483.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 66720
Product name : Methylene Blue hydrate
Purity: purum p.a., for microscopy (Bact., Bot., Hist., Vit.), ≥97.0% (calc. based on dry substance, AT)
Packaging: 25G
Price: ₹4173.6
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M4159
Product name : Methylene Blue hydrate
Purity: suitable for nucleic acid staining, BioReagent
Packaging: 100G
Price: ₹10278.6
Updated: 2022/06/14
Buy: Buy

METHYLENE BLUE Chemical Properties,Usage,Production

Chemical Properties green fine crystalline powder
Uses Methylene blue is used as a dye for a number of different staining procedures, such as Wright's stain and Jenner's stain. Since it is a temporary staining technique, methylene blue can also be used to examine RNA or DNA under the microscope or in a gel. I
Uses Methylene blue is used as a dye in different staining procedures viz. Wright's stain and Jenner's stain. It also serves as an indicator and medicine. Further, it is used to examine RNA and DNA under the microscope or in a gel. It is widely used as a redox indicator in analytical chemistry. It acts as a photosensitizer utilized to generate singlet oxygen in order to make organic peroxides by a Diels-Alder reaction. It is also used in the sulfide analysis. It plays an important role in aquaculture to treat fungal infections.
General Description Methylene Blue (MB) is a basic histological dye.
Biochem/physiol Actions Methylene blue is used as a bacteriologic stain or dye and indicator. It mediates the inactivation of enveloped viruses in plasma, when exposed to visible light. It is an inhibitor of nitric oxide synthase and guanylate cyclase. It also plays a key role in medicine as an antimalarial agent, reducing agent in methemoglobinemia and inducer of apoptosis in cancer cells.

in vivo

Methylene blue (Basic Blue 9) hydrate (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition^[1].
Methylene blue hydrate (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau^[2].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior^[3].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor^[3].

Animal Model:	Male NMRI mice^[1]
Dosage:	50 and 100 mg/kg
Administration:	Intraperitoneal injection; once, for 25 minutes
Result:	Reduced the prepulse inhibition and reduced the increase in locomotor activity caused by phencyclidine (PCP).

Animal Model:	CaMKIIα-tTA transactivator mice^[2]
Dosage:	20 and 40 mg/kg
Administration:	Oral administration; daily, for 6 months
Result:	Inhibited Tau aggregation in CaMKIIα-tTA transactivator mice.

Animal Model:	TBI-treated male BALB/c mice^[3]
Dosage:	2 mg/kg
Administration:	Intravenous injection; once, for 1 day
Result:	Decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA.

Animal Model:	TBI-treated male BALB/c mice^[3]
Dosage:	2 mg/kg
Administration:	Intravenous injection; once, for 1 day
Result:	Reduced the percentage of myeloid (CD11b+/GR1+) cells, reduced IL-1β and enhanced IL-10 expression in microglia.

METHYLENE BLUE Preparation Products And Raw materials

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