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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Structure
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
  • CAS No.42895-58-9
  • Chemical Name:14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
  • CBNumber:CB6735337
  • Molecular Formula:C20H28O4
  • Formula Weight:332.43
  • MOL File:42895-58-9.mol
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Property
  • Melting point 204-205℃
  • Boiling point 519.6±50.0 °C(Predicted)
  • Density 1.17
  • storage temp. Store at -20°C
  • solubility DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
  • pka 14.80±0.70(Predicted)
  • form Solid
  • color White to off-white
  • FDA UNII 5S0X4YZJ0E
  • UNSPSC Code 85151701
  • NACRES NA.24
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 55549
  • Product name : 14-Deoxy-11,12-didehydroandrographolide
  • Purity: analytical standard
  • Packaging: 5MG
  • Price: ₹31533.23
  • Updated: 2022/06/14
  • Buy: Buy

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemical Properties,Usage,Production

  • Description 14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.
  • Uses 14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
  • Definition ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.
  • in vivo

    14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine[1].

  • IC 50 NF-κB
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Suppliers
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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Spectrum
42895-58-9, 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDERelated Search:
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  • 14-脱氧-11,12-二去氢穿心莲内酯,10 MM DMSO 溶液
  • 14-脱氧-11,12-二氢穿心莲内酯
  • 14-去氧11,12去氧穿心莲内酯
  • 14一去氧-11,12一二脱氢穿心莲内脂
  • 14-脱水穿心莲内酯
  • 穿心莲内酯杂质1
  • 14-去氧-11
  • 12-二去氢穿心莲内酯
  • 14-脱氧-11,12-二去氢穿心莲内酯
  • 14-脱氧11,14-二脱氢穿心莲内酯
  • 14-脱氧-11,12-二去氢穿心莲内酯, >98%
  • 14-脱氧-11,12- 穿心莲内酯
  • 穿心莲内酯 穿心莲乙素
  • 14-去氧-11,12-二去氢穿心莲内酯
  • 雄茸交酯
  • 42895-58-9
  • 14-Deoxy-11,12-didehydroandrographolide, 10 mM in DMSO
  • Deoxy 11,14-didehydroandrographolide
  • 14-Deoxy 11,14-didehydroandrographolide-RM
  • 14 - deoxy11,12-12 dehydroandrographolide
  • 14-deoxy11,12 deoxyandrographolide
  • 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one
  • Andrographolide Impurity 1
  • 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP
  • 14-dehydro Andrographolide
  • 2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-
  • 14-Deoxy-11,12-didehydroandrographolide?, >98%
  • 3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one
  • 3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide
  • 14-Deoxy-11,12-didehydroandrographolide16,15-olide
  • 14-Deoxy-11,12-didehydroandrographol
  • 3-[(E)-2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-(hydroxymethyl)-5,8aα-dimethyl-2-methylenenaphthalen-1-yl]vinyl]furan-2(5H)-one
  • 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-6α-hydroxy-5,8aα-dimethyldecahydronaphthalene-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
  • 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
  • Deoxy-11,12-Didehydroandrographolide, 14-
  • AP 10
  • 14-Deoxy-11,14-didehydroandrographolide
  • 11,12-Didehydro-14-deoxyandrographolide
  • ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide
  • 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone
  • 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

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