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(R)-CPP

(R)-CPP Structure
(R)-CPP
  • CAS No.126453-07-4
  • Chemical Name:(R)-CPP
  • CBNumber:CB6725314
  • Molecular Formula:C8H17N2O5P
  • Formula Weight:252.2
  • MOL File:126453-07-4.mol
(R)-CPP Property
  • Boiling point 546.7±60.0 °C(Predicted)
  • Density 1.408±0.06 g/cm3(Predicted)
  • storage temp. Desiccate at RT
  • solubility Water: 100mM
  • form White crystalline powder.
  • pka 1.89±0.20(Predicted)
  • color White to off-white
  • Water Solubility Soluble to 100 mM in water
  • FDA UNII A3QV2VT7SN
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

(R)-CPP Chemical Properties,Usage,Production

  • Description (R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).
  • Uses (R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
  • Biological Activity Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).
  • IC 50 NMDA Receptor
  • storage Room temperature (desiccate)
(R)-CPP Preparation Products And Raw materials
Raw materials
Preparation Products
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(R)-CPP Spectrum
126453-07-4, (R)-CPPRelated Search:
  • Glutamate receptor
  • Glutamate
  • 抑制剂
  • C8H17N2O5P
  • (R)-CPP (MM/ML),NMDA拮抗剂
  • (R)-CPP,NMDA拮抗剂
  • 化合物 (R)-CPP
  • (R)-4-(3-膦酸丙基)哌嗪-2-羧酸
  • (2R)-4-(3-膦酰基丙基)-2-哌嗪羧酸
  • (R)-4-(3-膦酰基丙基)哌嗪-2-羧酸
  • 化合物 T23222
  • 126453-07-4
  • (R)-CPP (mM/ml), NMDA antagonist
  • (R)-CPP, NMDA antagonist
  • (R)CPP,(R) CPP
  • (R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid
  • 2-Piperazinecarboxylic acid, 4-(3-phosphonopropyl)-, (2R)-
  • CPP (R)-
  • 3-[(2R)-2-Carboxypiperazine-4-yl]propane-1-ylphosphonic acid
  • [3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid
  • rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid
  • rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid
  • rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid
  • 3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid
  • 3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
  • 3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
  • D-CPP
  • R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
  • (R)-CCP
  • (R)-CPP

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