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SULBENICILLIN

SULBENICILLIN Structure
SULBENICILLIN
  • CAS No.41744-40-5
  • Chemical Name:SULBENICILLIN
  • CBNumber:CB6715306
  • Molecular Formula:C16H18N2O7S2
  • Formula Weight:414.45
  • MOL File:41744-40-5.mol
SULBENICILLIN Property
  • Melting point 197 °C (decomp)
  • Density 1?+-.0.1 g/cm3(Predicted)
  • pka 0.28±0.50(Predicted)
  • FDA UNII Q2VYF0562D
  • ATC code J01CA16
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

SULBENICILLIN Chemical Properties,Usage,Production

  • Originator Lillacillin,Takeda,Japan,1973
  • Definition ChEBI: A penicillin antibiotic having a 6beta-[phenyl(sulfo)acetamido] side-chain.
  • Manufacturing Process To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts by volume of water is added 1.48 parts by weight of sodium bicarbonate. After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually added thereto. The mixture is stirred at a temperature in the neighborhood of 0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of portions of ether and adjusted to pH 1.2 with cation exchange resin of polystyrene sulfonic acid type under constant cooling. Then the solution is washed twice with 15 parts by volume of portions of ethyl acetate, followed by extraction twice with 15 parts by volume of portions of n-butanol. The extracts are combined and washed twice with 15 parts by volume of portions of water and, then, extracted with an aqueous solution of sodium bicarbonate. The extract is adjusted to pH 6.5, washed with ether and lyophilized to give the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.
  • Therapeutic Function Antibacterial
  • Antimicrobial activity α-Sulfobenzylpenicillin, a semisynthetic penicillin supplied as the disodium salt. Its antimicrobial spectrum and pharmacokinetic pharmacokinetic behavior closely resemble those of carbenicillin. Following intravenous administration of 4 g, the mean plasma concentration at 1 h was approximately 160 mg/L, with a plasma elimination half-life of around 70 min. It is largely excreted in the urine, about 80% of the dose appearing in the first 24 h, less than 5% as the penicilloic acid. It has been noted that the penicilloic acid causes much stronger platelet aggregation than its parent. It is of very limited availability.
SULBENICILLIN Preparation Products And Raw materials
Raw materials
Preparation Products
SULBENICILLIN Suppliers
Global(48)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
SULBENICILLIN Spectrum
41744-40-5, SULBENICILLINRelated Search:
  • 原料药
  • 医药原料
  • 医用原料
  • 化合物 T20254
  • 磺苄青霉素
  • 磺苄西林
  • 41744-40-5
  • Sulbenicilina
  • Kedacillina
  • SULBENICILLIN USP/EP/BP
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-, (2S,5R,6R)-
  • (2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenyl-2-sulfo-acetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfo-ethanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfoacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • (2S,5R,6R)-6-((S)-Carbamoyl(phenyl)methanesulfonoyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 6α-[(R)-Phenyl(sulfo)acetylamino]penicillanic acid
  • (R)-Sulbenicillin
  • (2S,5β)-3,3-Dimethyl-7-oxo-6α-[[(R)-phenyl(sulfo)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid
  • Sulbenicillin, D-(-)-
  • SBPC
  • D-(-)-Sulbenicillin
  • a-Sulfobenzylpenicillin
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2R)-phenylsulfoacetyl]amino]-, (2S,5R,6R)- (9CI)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, [2S-[2a,5a,6b(S*)]]-
  • Subenicillin
  • SULBENICILLIN

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