Preparation
pyridine is reluctant to undergo electrophilic nitration, pyridine-N-oxide is activated to electrophilic attack and nitration gives 4-nitropyridine-N-oxidel.
Chemical Properties
white to light yellow crystal
Uses
4-Nitropyridine
N-oxide may be used in the preparation of several 4-substituted pyridine-
N-oxides and pyridines.
Uses
The N-oxide derivative of a nitrated pyridine that has been shown to inhibit Na,K-ATPase activity. 4-Nitropyridine N-Oxide is a quorum sensing inhibitor.
General Description
Solid.
Air & Water Reactions
May be deliquescent.
Reactivity Profile
Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.
Health Hazard
High toxicity via oral exposure.
Fire Hazard
When heated to decomposition, 4-Nitropyridine N-oxide emits very toxic fumes of nitrogen oxides. Avoid decomposing heat.
Safety Profile
Poison by ingestion and skincontact. Questionable carcinogen with experimentaltumorigenic data. Mutation data reported. Mixtures withdiethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylateexplode when heated above 130°C. When heated todecompositio
