Chemical Properties
yellow-brown crystals or powder
Uses
4-Nitroquinoline
N-oxide has been used as a model compound to study its carcinogenic effects.
Uses
4-Nitroquinoline N-Oxide is used in method for constructing animal model of oral mucosal malignancy related to Kras mutation.
Definition
ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4.
General Description
Yellowish-brown plates or needles or yellow solid.
Air & Water Reactions
4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water.
Reactivity Profile
4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents.
Health Hazard
ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.
Fire Hazard
Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible.
Biochem/physiol Actions
Skin and lung tumor initiator under experimental conditions.
Safety Profile
Suspected carcinogen
with experimental carcinogenic, neoplas tigenic,
and tumorigenic data. Poison by
intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental
reproductive effects. Human mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx.
Purification Methods
The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.]
