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SULFISOXAZOLE ACETYL (200 MG)

SULFISOXAZOLE ACETYL (200 MG) Structure
SULFISOXAZOLE ACETYL (200 MG)
  • CAS No.80-74-0
  • Chemical Name:SULFISOXAZOLE ACETYL (200 MG)
  • CBNumber:CB6500542
  • Molecular Formula:C13H15N3O4S
  • Formula Weight:309.3409
  • MOL File:80-74-0.mol
SULFISOXAZOLE ACETYL (200 MG) Property
  • Melting point 193-194°
  • Boiling point 538.1±60.0 °C(Predicted)
  • Density 1.3541 (rough estimate)
  • refractive index 1.6320 (estimate)
  • pka -0.17±0.10(Predicted)
  • form Solid
  • color White to off-white
  • Water Solubility 80mg/L(37 ºC)
  • FDA UNII WBT5QH3KED
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • HS Code  :2935904000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

SULFISOXAZOLE ACETYL (200 MG) Chemical Properties,Usage,Production

  • Originator Gantrisin Acetyl ,Roche ,US ,1954
  • Uses Sulfisoxazole Acetyl is an antibiotic used in the prevention of infection especially when used in conjunction with erythromycin.
  • Uses Antibacterial.
  • Definition ChEBI: Sulfisoxazole acetyl is a sulfonamide and a member of benzenes.
  • Manufacturing Process 267 grams (1 mol) of sulfisoxazole were suspended in 400 ml of acetone and 79 grams (1 mol) of dry pyridine at 20-25°C in a round-bottom flask equipped with a stirrer and thermometer. 132 grams (1 mol) of acetic anhydride were added within 3 minutes with stirring. The sulfisoxazole dissolved in the mixture and a clear solution resulted. The temperature rose to 39-40°C. After stirring for several minutes, the product started to crystallize as a white crystalline mush. The temperature rose to 42-43°C maintained itself at this temperature for 15-30 minutes, and then started to drop. Stirring was continued for 5 hours and the mixture was then allowed to stand for 10 hours. One liter of 2.5-3.0% ice-cold aqueous ammonia and some fresh ice were then added while stirring and the crystals were filtered without delay. The crystals were washed on the filter with 1 liter of ice-cold 1% ammonia and then with 1 liter of water. The material on the filter was well pressed off, washed with 200-300 ml of alcohol and dried at 70°C to constant weight. The N-monoacetyl sulfisoxazole melted at 193-194°C and showed a positive Bratton-Marshall reaction and a positive Hucknall-Turfat reaction.
    The product is in the form of colorless crystals which are somewhat water repellent. It is insoluble in alkali but is saponified upon standing in alkaline suspension (3% ammonia). It is soluble in strong acids (20-36% HCl or 10 N H2SO4) and is rapidly saponified upon standing.
  • brand name Gantrisin (Roche).
  • Therapeutic Function Antimicrobial
  • General Description Sulfisoxazole acetyl shares the actions and usesof the parent compound, sulfisoxazole. The acetyl derivativeis tasteless and, therefore, suitable for oral administration, especiallyin liquid preparations. The acetyl compound is splitin the intestinal tract and absorbed as sulfisoxazole; that is, itis a prodrug for sulfisoxazole.
SULFISOXAZOLE ACETYL (200 MG) Preparation Products And Raw materials
Raw materials
Preparation Products
SULFISOXAZOLE ACETYL (200 MG) Suppliers
Global(50)Suppliers
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SULFISOXAZOLE ACETYL (200 MG) Spectrum
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  • 80-74-0
  • <i>N</i>-[(4-Aminophenyl)sulfonyl]-<i>N</i>-(3,4-dimethyl-5-isoxazolyl)acetamide
  • Sulfisoxazole acetyl, 10 mM in DMSO
  • Inhibitor,antibacterial action,N1-Acetylsulfisoxazole,inhibit,Bacterial,Sulfisoxazole acetyl,Sulfisoxazole derivative,orally active,dihydropteroate synthase
  • Gantrisin Pediatric
  • Sulfisoxazole Acetyl (1639003)
  • SULFISOXAZOLE ACETYL (200 MG) USP/EP/BP
  • ASIZ
  • N1-Acetylsulfisoxazole
  • 1-(oxazol-2-ylsulfinyl)ethanone
  • N-(4-azanylphenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)ethanamide
  • N-(4-aminophenyl)sulfonyl-N-(3,4-dimethylisoxazol-5-yl)acetamide
  • N-(4-aminophenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide
  • N-(4-Aminophenylsulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)acetamide
  • 5-[N-Acetyl-N-(p-aminophenylsulfonyl)amino]-3,4-dimethylisoxazole
  • acetylsulfafurazole
  • N-3,4-dimethylisoxazol-5-yl-N-sulphanilylacetamide
  • Sulfisoxazole Acetyl
  • N-Acetyl-4-amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
  • n-3,4-dimethylisoxazol-5-yl-n-sulfanilylacetamide
  • N-(3,4-Dimethyl-5-isoxazolyl)-N-sulfanilylacetamide
  • Lipo Gantrisin
  • Acetyl sulfisoxazole
  • Acetamide, N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)-
  • SULFISOXAZOLE ACETYL (200 MG)

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