Chemical Properties
light yellow powder
Uses
(1
R,2
R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol may be used in the preparation of (1
R,2
R)-(-)-2-dimethylamino-1-(4-nitrophenyl)-1,3-propanediol via
N,
N-dimethylation. It may also be used as a starting material to synthesize (1
R,2
R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothioeyanate [(
R,
R)-DANI].
Uses
D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuel
ae.
Uses
Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.
Definition
ChEBI: A diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively.
