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H-ARG-GLN-OH HYDROCHLORIDE SALT

H-ARG-GLN-OH HYDROCHLORIDE SALT Structure
H-ARG-GLN-OH HYDROCHLORIDE SALT
  • CAS No.2483-17-2
  • Chemical Name:H-ARG-GLN-OH HYDROCHLORIDE SALT
  • CBNumber:CB6429890
  • Molecular Formula:C11H22N6O4
  • Formula Weight:302.33
  • MOL File:2483-17-2.mol
H-ARG-GLN-OH HYDROCHLORIDE SALT Property
  • storage temp. -15°C
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

H-ARG-GLN-OH HYDROCHLORIDE SALT Chemical Properties,Usage,Production

  • Uses Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].
  • Definition ChEBI: Arg-Gln is a dipeptide formed from L-arginyl and L-glutamine residues. It has a role as a metabolite.
  • in vivo

    Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) dramatically inhibits retinal neovascularization in the mouse oxygen-induced retinopathy (OIR) model[1].

    Animal Model:C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model[1]
    Dosage:1.0, 2.5, or 5 g/kg per day
    Administration:Intraperitoneal injection, twice daily
    Result:Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day.
  • References [1] Neu J, et al. The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5. DOI:10.1167/iovs.05-1473
H-ARG-GLN-OH HYDROCHLORIDE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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H-ARG-GLN-OH HYDROCHLORIDE SALT Spectrum
2483-17-2, H-ARG-GLN-OH HYDROCHLORIDE SALTRelated Search:
  • 多肽
  • 606335
  • (2S)-5-AMINO-2-[[(2S)-2-AMINO-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]-5-OXOPENTANOIC ACID
  • 2483-17-2
  • Arg-Gln
  • (S)-5-Amino-2-((S)-2-amino-5-guanidinopentanamido)-5-oxopentanoic acid
  • L-Glutamine, L-arginyl-
  • H-Arg-Gln-OH
  • H-ARG-GLN-OH HYDROCHLORIDE SALT
  • H-ARG-GLN-OH HCL

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