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Drometrizole

Characterization Applications Features/benefits Guidelines for use Physical Properties Safety

Drometrizole

CAS No.2440-22-4
Chemical Name:Drometrizole
CBNumber:CB6426334
Molecular Formula:C13H11N3O
Formula Weight:225.25
MOL File:2440-22-4.mol

Drometrizole Property

Melting point 125.5-129.5 °C(lit.)
Boiling point bp10 225°
Density 1.38
vapor pressure 0Pa at 20℃
refractive index 1.5600 (estimate)
Flash point 54°C
storage temp. 15-25°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 8.15±0.43(Predicted)
color Off-White to Pale Yellow
Water Solubility 173μg/L at 20℃
Merck 14,3447
Stability Hygroscopic
InChIKey MCPKSFINULVDNX-UHFFFAOYSA-N
LogP 4.2 at 25℃
CAS DataBase Reference 2440-22-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances 2-(2'-HYDROXY-5'-METHYLPHENYL)BENZOTRIAZOLE
EWG's Food Scores 1-2
FDA UNII 5X93W9OFZL
NIST Chemistry Reference Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-(2440-22-4)
EPA Substance Registry System 2-(2H-Benzotriazol-2-yl)-p-cresol (2440-22-4)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :36/37/38-53-43
Safety Statements :22-24/25-36/37
WGK Germany :1
RTECS :GO6860000
HS Code :29339900
Toxicity :LD50 oral in mouse: 6500mg/kg

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H317-H410
Precautionary statements P261-P272-P273-P280-P302+P352-P333+P313

Drometrizole Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: CRM96697
Product name : 2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity: certified reference material, TraceCERT?
Packaging: 100MG
Price: ₹14310.65
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 533203
Product name : 2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity: 97%
Packaging: 25G
Price: ₹7869.78
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: H0560
Product name : 2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity:
Packaging: 25G
Price: ₹5400
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: H0560
Product name : 2-(2-Hydroxy-5-methylphenyl)benzotriazole
Purity:
Packaging: 500G
Price: ₹10600
Updated: 2022/05/26
Buy: Buy

Drometrizole Chemical Properties,Usage,Production

Characterization Drometrizole is an ultraviolet light absorber (UVA) of the hydroxyphenyl benzotriazole class, imparting good light stability to a wide variety of polymers.
Applications Drometrizole provides ultraviolet protection in a wide variety of polymers including styrene homoand copolymers, engineering plastics such as polyesters and acrylic resins, polyvinyl chloride, and other halogen containing polymers and copolymers (e.g. vinylidenes), acetals and cellulose esters. Elastomers, adhesives, polycarbonate blends, polyurethanes, and some cellulose esters and epoxy materials also benefit from the use of Drometrizole.
Features/benefits Drometrizole features a strong absorption of ultraviolet radiation in the 300-400 nm region. It also has a high degree of photostability over long periods of light exposure. The high absorbance combined with photostability and the ability to release absorbed energy in non sensitizing ways make Drometrizole an effective stabilizer against the effects of ultraviolet light.
Guidelines for use The use levels of Drometrizole range between 0.10% and 0.50%, depending on substrate and performance requirements of the final application. Drometrizole can be used alone or in a variety of blends and combinations with Ciba IRGAFOS®, Ciba IRGANOX® and Ciba CHIMASSORB® stabilizers where often a synergistic performance is observed. Drometrizole may react with various heavy metal ions to form salts or complexes. For example, if Drometrizole comes into contact with iron or cobalt ions, colored complexes are formed. Reducing and oxidizing agents used in polymerization and curing processes have no effect on the stability of Drometrizole.
Physical Properties
Safety In accordance with good industrial practice, handle with care and avoid unnecessary personal contact. Protect skin. Prevent contamination of the environment. Avoid dust formation and ignition sources.
Chemical Properties Light yellow powder
Uses Drometrizole is an intermediate reactant in the synthesis of UV light absorbers for polyester fibers.
Uses 2(2-Hydroxy-5-methylphenyl)benzotriazol is an UV adsorber for use in plastics, cosmetics, dental materials, acrylic materials, dyes, etc.
Uses An ultraviolet light absorber for stabilizing plastics and other organic materials against discoloration and deterioration.
Application Intermediate reactant in the synthesis of UV light absorbers for polyester fibers
Reactant for synthesis of:
Benzotriazole UV absorbers with a blocked hydroxy group for us in UV curable paint
Maleimide-bound benzotriazole monomer to use for emulsion polymerization
Used in:
Microstereophotolithography and shape memory alloy for fabrication of miniaturized actuators
PVS and wood / PVC composites as a stabilizer
Acrylonitrile-butadiene-styrene as a UV absorber.
Definition Drometrizole is a member of triazoles.
Flammability and Explosibility Not classified
reaction suitability reaction type: C-C Bond Formation
Toxicity evaluation The mutagenicity study of drometrizole was performed using Salmonella typhimurium strains TA1538 and TA98 with metabolic activation in the Ames’ test. Spot test (10 and 100 mg drometrizole/plate) and top agar method (50 and 100 mg drometrizole/plate) were conducted. The results showed that drometrizole was not mutagenic.Mice and rats were administered 5.0 or 10.0 g/kg of drometrizole in sunflower oil by stomach tube intubation. After body weight and behaviour were monitored for 3 weeks, acute toxicity of drometrizole was evaluated to be low. The oral lethal dose (LD50) of drometrizole in mice was reported to be 6.5 g/kg and > 5.0g/kg. Oral toxicity was evaluated in rats for nail care cosmetics containing 1%, 0.3% and 0.03% of drometrizole. The LD50 of products containing 1% of drometrizole was > 15.0 g/kg. The LD50 of products containing 0.3% and 0.03% drometrizole was > 5.0 g/kg. No acute toxicity was observed in these treatments.