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L-Citrulline

CAS No.372-75-8
Chemical Name:L-Citrulline
CBNumber:CB6423883
Molecular Formula:C6H13N3O3
Formula Weight:175.19
MOL File:372-75-8.mol

L-Citrulline Property

Melting point 214 °C
Boiling point 306.48°C (rough estimate)
alpha 25.5 º (c=8, 6N HCl)
Density 1.2919 (rough estimate)
refractive index 26 ° (C=8, 6mol/L HCl)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (Sparingly). Water (Slightly)
pka 2.43(at 25℃)
form Crystals or Crystalline Powder
color White
Odor Odorless
optical activity +4.025 (H2O) +24.225 (1 mol dm-3 HCl)
Water Solubility 200 g/L (20 ºC)
Merck 14,2331
BRN 6055157
InChIKey RHGKLRLOHDJJDR-BYPYZUCNSA-N
LogP -3.190
CAS DataBase Reference 372-75-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 29VT07BGDA
NCI Drug Dictionary L-citrulline
EPA Substance Registry System L-Ornithine, N5-(aminocarbonyl)- (372-75-8)
UNSPSC Code 41116107
NACRES NA.32

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :24/25-36-26
WGK Germany :3
TSCA :Yes
HS Code :29241900

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P280-P305+P351+P338

L-Citrulline Price More Price(19)

Brand: Sigma-Aldrich(India)
Product number: C7629
Product name : L-Citrulline
Purity: ≥98% (TLC)
Packaging: 10MG
Price: ₹2413.98
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C7629
Product name : L-Citrulline
Purity: ≥98% (TLC)
Packaging: 5G
Price: ₹3442.35
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C7629
Product name : L-Citrulline
Purity: ≥98% (TLC)
Packaging: 1G
Price: ₹4351.65
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C7629
Product name : L-Citrulline
Purity: ≥98% (TLC)
Packaging: 25G
Price: ₹7902.25
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C7629
Product name : L-Citrulline
Purity: ≥98% (TLC)
Packaging: 100G
Price: ₹26997.55
Updated: 2022/06/14
Buy: Buy

L-Citrulline Chemical Properties,Usage,Production

Chemical Properties White powder
Originator StaminO2,ErgoPharm
Uses L-Citrulline, is used as an essential intermediate in the biosynthesis of nitric oxide from L-arginine . It is also used as a nutritional drink and biochemical reagent.
Uses An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide.
Definition ChEBI: L-citrulline is the L-enantiomer of citrulline. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a protective agent, a nutraceutical, a micronutrient, a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is an enantiomer of a D-citrulline. It is a tautomer of a L-citrulline zwitterion.
Manufacturing Process Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with sodium hydroxide, copper oxide and hydrogen sulfide.
In practice it is usually used as malate salt
Therapeutic Function Stimulant, Detoxicant
benefits L-citrulline is used for Alzheimer's disease, dementia, fatigue, muscle weakness, sickle cell disease, erectile dysfunction, high blood pressure, and diabetes. It is used for heart disease, body building, increasing energy, and for improving athletic performance.
Biochem/physiol Actions L-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.
target NO | IL Receptor
Drug interactions There are no reported side effects of L-citrulline.
However, the supplement may affect the way certain drugs work in your body. Do not take this supplement if you are taking:
Nitrates for heart disease
ED drugs such as sildenafil (Revatio, Viagra), tadalafil (Cialis), or vardenafil (Levitra, Staxyn)
Combining L-citrulline with those drugs may cause a dangerous drop in blood pressure.
You should also be careful when taking L-citrulline if you take any type of blood pressure medicine.
Do not use L-citrulline if you are pregnant or breastfeeding.
Purification Methods Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.]