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Z-VDVAD-FMK

Z-VDVAD-FMK Structure
Z-VDVAD-FMK
  • CAS No.210344-92-6
  • Chemical Name:Z-VDVAD-FMK
  • CBNumber:CB6364843
  • Molecular Formula:C32H46FN5O11
  • Formula Weight:695.73
  • MOL File:Mol file
Z-VDVAD-FMK Property
  • storage temp. −20°C
  • solubility DMSO/DMF: 20 mM
  • form powder
  • color white
  • biological source synthetic (organic)
  • UNSPSC Code 12352209
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Z-VDVAD-FMK Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: C1605
  • Product name : Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone
  • Purity: powder, ≥95%
  • Packaging: 1MG
  • Price: ₹56636.4
  • Updated: 2022/06/14
  • Buy: Buy

Z-VDVAD-FMK Chemical Properties,Usage,Production

  • Uses Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].
  • Biological Activity Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
  • Biochem/physiol Actions A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.
  • IC 50 Caspase-2
  • References 1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate specificity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223.
Z-VDVAD-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
Z-VDVAD-FMK Suppliers
Global(63)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
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  • Tel：821-50328103-801<br/>18930552037
  • Email：3bsc@sina.com
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  • Supplier： GL Biochem (Shanghai) Ltd
  • Tel：21-61263452<br/>13641803416
  • Email：ymbetter@glbiochem.com
  • Country：China
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  • Advantage：64
  • Supplier： VDM Biochemicals
  • Tel：0330-2528181
  • Email：sales@vdmbio.com
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  • Supplier： Alabiotech Inc.
  • Tel：001-619-354-5251
  • Email：sales@alabiotech-e.com
  • Country：United States
  • ProdList：972
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Z-VDVAD-FMK Spectrum
210344-92-6, Z-VDVAD-FMKRelated Search:
  • Caspase/Related Products
  • Caspases/Apoptosis
  • C32H46FN5O11
  • C32H46N5O11F
  • METHYL 5-FLUORO-3-[2-[[2-[[4-METHOXY-2-[[3-METHYL-2-(PHENYLMETHOXYCARBONYLAMINO)BUTANOYL]AMINO]-4-OXOBUTANOYL]AMINO]-3-METHYLBUTANOYL]AMINO]PROPANOYLAMINO]-4-OXOPENTANOATE
  • 210344-92-6
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-α-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
  • Z-VD(OME)VAD(OME)-FMK
  • Z-VD(OME)VAD(OME)-FLUOROMETHYLKETONE
  • Z-VDVAD-FMK
  • Z-VDVAD-FLUOROMETHYLKETONE
  • Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE
  • Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK
  • Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
  • Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE
  • CASPASE-2 INHIBITOR I
  • BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

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