ChemicalBook > CAS DataBase List > 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Structure
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
  • CAS No.6981-18-6
  • Chemical Name:5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
  • CBNumber:CB6333201
  • Molecular Formula:C14H18N4O2
  • Formula Weight:274.32
  • MOL File:6981-18-6.mol
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Property
  • Melting point 231.0 to 235.0 °C
  • Boiling point 521.5±60.0 °C(Predicted)
  • Density 1.223±0.06 g/cm3(Predicted)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • solubility Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
  • form Solid
  • pka 7.11±0.10(Predicted)
  • color Off-White
  • Water Solubility Water: Insoluble
  • λmax 287nm(CHCl3)(lit.)
  • Stability Hygroscopic
  • FDA 21 CFR 556.490; 558.4
  • CAS DataBase Reference 6981-18-6(CAS DataBase Reference)
  • FDA UNII M3EFS94984
  • EPA Substance Registry System Ormetoprim (6981-18-6)
Safety
  • Safety Statements  :24/25
  • HS Code  :29333990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Chemical Properties,Usage,Production

  • Uses It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).
  • Definition ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.
  • Synthesis Reference(s) Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029
  • in vivo

    Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3].
    Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3].

    Animal Model:Hybrid striped bass (565-805 g)[3]
    Dosage:50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)
    Administration:I.p. and p.o. administration
    Result:I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL.
    P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%.
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Suppliers
Global(172)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
  • ProdList：965
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15349
  • Advantage：58
5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Spectrum
6981-18-6, 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidineRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Heterocycles
  • Active Pharmaceutical Ingredients
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 生化试剂
  • 有机化学
  • 兽用原料
  • 化学试剂
  • 原料药
  • 原料药
  • 医药原料
  • 其他兽药标准品
  • 兽药
  • 抗生素
  • 奥美普林,10 MM DMSO 溶液
  • 甲藜嘧胺
  • 乙腈中奥美普林
  • 乙腈中二甲氧甲基苄胺嘧啶(奥美普林)溶液标准物质
  • 甲醇中二甲氧甲基苯氨嘧啶溶液
  • 甲醇中二甲氧甲基苯氨嘧啶
  • 二甲氧甲基苯氨嘧啶溶液
  • 5-(4,5-二甲氧基-2-甲基苄基)嘧啶-2,4-二胺
  • 奥美普林/甲藜嘧胺 标准品
  • 奥美普林标准品
  • 奥美普林
  • 二甲氧甲基苯氨嘧啶(甲黎嘧啶)
  • 奥美普林/甲藜嘧胺
  • 二甲氧甲基苯氨嘧啶溶液, 100PPM
  • 二甲氧甲基苯氨嘧啶
  • 邻里氧普林
  • 5-(4,5-二甲氧基-2-甲基苄基)-2,4-二氨嘧啶
  • 6981-18-6
  • Ormetoprim - Bio-X ?
  • Ormetoprim, 10 mM in DMSO
  • Omeprin
  • 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine
  • Ormetoprim Standard
  • Ormetoprim&gt
  • 2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
  • 2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine
  • 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine USP/EP/BP
  • 6981-18-6 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
  • N'-Diphenylguanidine
  • NSC 3272
  • NSC3272
  • NSC-3272
  • 5-[(4,5-Dimethoxy-2-methyl)phenylmethyl]-2,4-pyrimidine
  • Ro 5-9754
  • NSC-95072
  • 5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine
  • 2,4-Diamino-5-(6-methylveratryl)pyrimidine
  • DiaMino-5-(6-Methylveratryl)pyriMidine
  • 2,4-DiaMino-5-92-Methyl-4,5- diMethoxybenzyl)pyriMidine
  • L-Ascorbic Phosphate Magnesium
  • 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

Home

My