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[D-PRO2, D-TRP7,9]-SUBSTANCE P

[D-PRO2, D-TRP7,9]-SUBSTANCE P Structure
[D-PRO2, D-TRP7,9]-SUBSTANCE P
  • CAS No.80434-86-2
  • Chemical Name:[D-PRO2, D-TRP7,9]-SUBSTANCE P
  • CBNumber:CB6321749
  • Molecular Formula:C74H106N20O13S
  • Formula Weight:1515.82
  • MOL File:80434-86-2.mol
[D-PRO2, D-TRP7,9]-SUBSTANCE P Property
  • storage temp. −20°C
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

[D-PRO2, D-TRP7,9]-SUBSTANCE P Chemical Properties,Usage,Production

  • Uses [D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].
  • in vivo

    [D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1].
    [D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2].

    Animal Model:Adult pigmented rabbits (1.5-3 kg)[1]
    Dosage:0.03, 0.3, 3, and 30 nmol
    Administration:Intravitreal injection or topical application onto the eye, 60 μL
    Result:Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
  • References [1] Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. DOI:10.1126/science.6171036
    [2] H?kanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. DOI:10.1111/j.1476-5381.1982.tb09348.x
    [3] Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. DOI:10.5114/fn.2020.100066
[D-PRO2, D-TRP7,9]-SUBSTANCE P Preparation Products And Raw materials
Raw materials
Preparation Products
[D-PRO2, D-TRP7,9]-SUBSTANCE P Suppliers
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[D-PRO2, D-TRP7,9]-SUBSTANCE P Spectrum
80434-86-2, [D-PRO2, D-TRP7,9]-SUBSTANCE PRelated Search:
  • 目录肽
  • 多肽
  • 标准品
  • Antagonist
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Peptides
  • Tachykinins
  • C74H106N20O13S
  • [D-PRO2,D-TRP,]-神经肽P物质
  • P物质肽[DPRO2, DTRP7, 9] SUBSTANCE P
  • D-PRO2, D-TRP7,9]-神经肽P物质
  • [D-PRO2, D-TRP7,9]-P 物质
  • 80434-86-2
  • [D-Pro2,D-Trp,]-Substance P
  • (D-Pro?,D-Trp?·?)-Substance P acetate salt
  • 2,D-Trp7,9>-SP
  • 17:PN:US20020037833 SEQID:16 unclaimed sequence
  • L-Methioninamide, L-arginyl-D-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-
  • 2-Pro-7,9-Trp-substance p
  • 2-Pro-7,9-Trp-sp
  • L-Arg-D-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
  • L-Arg-D-Pro-L-Lys-L-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Met-NH2
  • Substance P, (D-Pro2, D-Trp7,9) acetate
  • substance P, prolyl(2)-tryptophan(7,9)-
  • H-Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2
  • (D-pro2
  • [D-PRO2,D-TRP7,9]-SUBSTANCE P HYDROCHLORIDE
  • [D-PRO2,D-TRP7,9]-SUBSTANCE P 3HCL 6H2O
  • [D-PRO2, D-TRP7,9]-SUBSTANCE P
  • ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 HYDROCHLORIDE
  • ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 3HCL 6H2O
  • ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
  • dt79
  • (D-Pro2,D-Trp7
  • Substance p, Pro(2)-Trp(7,9)-
  • Substance p, 2-D-proline-7-D-tryptophan-9-D-tryptophan-
  • Pttsp
  • Pt-sp

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