Chemical Properties
clear colorless liquid. Quite powerful, fruity, Pear-like odor.
Uses
Diethyl Diethylmalonate is an intermediate in the synthesis of Barbital (B118500), a prototype of the barbiturate hypnotics.
Uses
manufacture of barbiturates.
Production Methods
This ester has been suggested for use in flavor compositions, but it is not sufficiently stable enough to become very popular. The ester has occasionally found use in perfume compositions, mainly as a modifier in fruity notes, winey top note bases, etc. Diethyl diethylmalonate is produced (several methods) e. g. by condensing Ethyl acetate with Ethyl oxalate, heat the resultant Oxaloacetic ester, and esterify the formed Diethyl malonic acid.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 578, 1942
DOI: 10.1021/ja01255a034
