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NPGB

NPGB Structure
NPGB
  • CAS No.19135-17-2
  • Chemical Name:NPGB
  • CBNumber:CB6287205
  • Molecular Formula:C14H13ClN4O4
  • Formula Weight:336.73
  • MOL File:19135-17-2.mol
NPGB Property
  • Melting point 241-243 °C
  • storage temp. -20°C
  • solubility formic acid: soluble 49.00-51.00mg/mL
  • form Solid
  • color White to off-white
  • BRN 8024554
  • UNSPSC Code 12352204
  • NACRES NA.32
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36
  • Safety Statements  :26
  • WGK Germany  :3
  • F  :8-10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H318
  • Precautionary statements P280-P305+P351+P338
NPGB Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: N8010
  • Product name : 4-Nitrophenyl 4-guanidinobenzoate hydrochloride
  • Purity: protease inhibitor and substrate
  • Packaging: 500MG
  • Price: ₹22570.13
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: N8010
  • Product name : 4-Nitrophenyl 4-guanidinobenzoate hydrochloride
  • Purity: protease inhibitor and substrate
  • Packaging: 1G
  • Price: ₹37238
  • Updated: 2022/06/14
  • Buy: Buy

NPGB Chemical Properties,Usage,Production

  • Uses 4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
    • as a substrate for trypsin for active site titration experiments
    • for pre-treating of mosquito eggs in the interplasmid transposition assay
    • as a component of isotonic buffer to moisten filter paper for mosquito embryo collection

  • General Description 4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
  • Biochem/physiol Actions 4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
  • References [1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
    [2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
    [3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
    [4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
    [5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.
NPGB Preparation Products And Raw materials
Raw materials
Preparation Products
NPGB Suppliers
Global(18)Suppliers
  • Supplier： ChemShuttle, Inc.
  • Tel：0150-83588313-811<br/>18800520310
  • Email：sales@chemshuttle.com
  • Country：China
  • ProdList：2999
  • Advantage：62
  • Supplier： Sigma-Aldrich
  • Tel：021-61415566<br/>800-8193336
  • Email：orderCN@merckgroup.com
  • Country：China
  • ProdList：51456
  • Advantage：80
  • Supplier： Energy Chemical
  • Tel：021-58432009<br/>400-005-6266
  • Email：marketing@energy-chemical.com
  • Country：China
  • ProdList：44918
  • Advantage：58
  • Supplier： Merck KGaA
  • Tel：21-20338288
  • Email：ordercn@merckgroup.com
  • Country：China
  • ProdList：292394
  • Advantage：58
NPGB Spectrum
19135-17-2, NPGBRelated Search:
  • Biochemicals and Reagents
  • BioChemical
  • Activity
  • Enzyme Substrates
  • Enzymes, Inhibitors, and Substrates
  • Chromogenic
  • Substrates by Enzyme
  • C14H12N4O4HCl
  • 4-胍基苯甲酸4-硝基苯酯盐酸盐
  • 19135-17-2
  • 4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate
  • (4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride
  • 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
  • Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride
  • p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline
  • p-nitrophenyl-p'-guanidinobenzoateHClcrystalline
  • 4-NITROPHENYL 4-GUANIDINOBENZOATE &
  • P-NITROPHENYL P'-GUANIDINOBENZOATE HCL
  • 4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride
  • Nsc163801
  • P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE
  • P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE
  • P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE
  • PNPGB
  • NPGB
  • 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
  • 4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE

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