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CYCLOSPORIN D

CYCLOSPORIN D Structure
CYCLOSPORIN D
  • CAS No.63775-96-2
  • Chemical Name:CYCLOSPORIN D
  • CBNumber:CB6276179
  • Molecular Formula:C63H113N11O12
  • Formula Weight:1216.64
  • MOL File:63775-96-2.mol
CYCLOSPORIN D Property
  • Melting point 148-1510C
  • alpha D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
  • Boiling point 1294.7±65.0 °C(Predicted)
  • Density 1.015±0.06 g/cm3(Predicted)
  • Flash point 9 °C
  • storage temp. -20°C Freezer
  • solubility Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
  • form Colorless to off-white crystalline solid.
  • pka 13.22±0.70(Predicted)
  • color White to Off-White
  • InChIKey YJDYDFNKCBANTM-QCWCSKBGSA-N
  • FDA UNII 8ZD3I5M2HF
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H302+H312+H332-H319
  • Precautionary statements P210-P280-P305+P351+P338
CYCLOSPORIN D Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: C-108
  • Product name : Cyclosporin D solution
  • Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging: 1ML
  • Price: ₹26240.9
  • Updated: 2022/06/14
  • Buy: Buy

CYCLOSPORIN D Chemical Properties,Usage,Production

  • Chemical Properties Colorless Crystalline Solid
  • Uses A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
  • Uses Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
  • Biological Activity cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].
  • in vivo

    Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1].

  • storage +4°C
  • References [1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
    [2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
    [3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
    [4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.
CYCLOSPORIN D Preparation Products And Raw materials
Raw materials
Preparation Products
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CYCLOSPORIN D Spectrum
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  • 原料药
  • C63H111N11O12
  • 化合物 CYCLOSPORIN D
  • 环孢素 EP 杂质 G(环孢素 D)
  • 环孢菌素杂质4(环孢菌素D)(环孢素EP杂质G)
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-羟基-2-甲基己基-4-烯-1-基)-6,9,18,24-四异丁基-3,21,30-三异丙基-1,4,7,10,12,15,19,25,28-九甲基-1,4,7,10,13,16,19,22,25,28,31-十一氮杂环三TRIACONTAN-2,5,8,11,14,17,20,23,26,29,32-十一酮
  • 环孢菌素杂质4(环孢菌素D)
  • 环孢素EP杂质G(环孢菌素D)
  • 环孢菌素D(环孢素EP杂质G)
  • 环孢素D(EP)
  • 环孢素杂质4
  • CYCLO ({AAA}-VAL-{SAR}-LEU-VAL-LEU-ALA-ALA-LEU-LEU-{D-VAL})
  • 环孢素杂质D
  • 环孢霉素杂质D
  • 环孢霉素D, 来源于小单孢菌
  • 环孢菌素杂质D
  • 环孢素D
  • 环孢菌素 D
  • 环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-缬氨酰-3-羟基-N,4-二甲基-L-2-氨基-6-辛烯酰-L-缬氨酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-缬氨酰-N-甲基-L-亮氨酰]
  • 环胞霉素 D
  • 环孢霉素D
  • 63775-96-2
  • Ciclosporin EP Impurity G
  • Ciclosporin EP Impurity G (Cyclosporin D)
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tris(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-Hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • Cyclosporin D, EvoPure?
  • Cyclosporin D (Ciclosporin EP Impurity G)
  • Cyclosporin Impurity 4(Cyclosporin D)(Ciclosporin EP Impurity G)
  • cyclosporin impurity D
  • Ring spore D
  • Cyclosporin DQ: What is Cyclosporin D Q: What is the CAS Number of Cyclosporin D Q: What is the storage condition of Cyclosporin D Q: What are the applications of Cyclosporin D
  • Cyclosporine Impurity 4
  • Cyclosporin A, 7-L-valine-
  • Cyclosporin DCyclosporine
  • CS-1740
  • Cyclosporine D/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
  • Cyclosporine EP Impurity D
  • Cyclosporin Impurity 4(Cyclosporin D)

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