ChemicalBook > CAS DataBase List > Spermine

Spermine

Spermine Structure
Spermine
  • CAS No.71-44-3
  • Chemical Name:Spermine
  • CBNumber:CB6275334
  • Molecular Formula:C10H26N4
  • Formula Weight:202.34
  • MOL File:71-44-3.mol
Spermine Property
  • Melting point 28-30 (lit.)
  • Boiling point 150 °C/5 mmHg (lit.)
  • Density 0.937
  • refractive index 1.4850 (estimate)
  • Flash point >230 °F
  • storage temp. 2-8°C
  • solubility H2O: 1 M at 20 °C, clear, colorless
  • form powder
  • pka 10.88±0.19(Predicted)
  • color Colorless to off-white
  • biological source microbial
    synthetic
  • Water Solubility Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
  • Sensitive Air Sensitive & Hygroscopic
  • Merck 14,8743
  • BRN 1751791
  • Stability Hygroscopic
  • InChIKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
  • LogP -0.543 (est)
  • CAS DataBase Reference 71-44-3(CAS DataBase Reference)
  • FDA UNII 2FZ7Y3VOQX
  • NIST Chemistry Reference Spermine(71-44-3)
  • EPA Substance Registry System 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)
  • UNSPSC Code 85151701
  • NACRES NA.75
Safety
  • Hazard Codes  :Xi,C
  • Risk Statements  :36/38-34
  • Safety Statements  :26-36-45-36/37/39-27
  • RIDADR  :UN 3259 8/PG 2
  • WGK Germany  :3
  • RTECS  :EJ7230000
  • F  :3-10
  • TSCA  :Yes
  • HazardClass  :8
  • PackingGroup  :III
  • HS Code  :29212900
  • NFPA 704:
    1
    3 1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H318-H314
  • Precautionary statements P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310
Spermine Price More Price(12)
  • Brand: Sigma-Aldrich(India)
  • Product number: S4264
  • Product name : Spermine
  • Purity: suitable for cell culture, BioReagent
  • Packaging: 1G
  • Price: ₹6397.58
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: S3256
  • Product name : Spermine
  • Purity: ≥97%
  • Packaging: 1G
  • Price: ₹6711.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: S4264
  • Product name : Spermine
  • Purity: suitable for cell culture, BioReagent
  • Packaging: 5G
  • Price: ₹27051.68
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: S3256
  • Product name : Spermine
  • Purity: ≥97%
  • Packaging: 5G
  • Price: ₹20166.98
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: S3256
  • Product name : Spermine
  • Purity: ≥97%
  • Packaging: 25G
  • Price: ₹66400.55
  • Updated: 2022/06/14
  • Buy: Buy

Spermine Chemical Properties,Usage,Production

  • Description Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.
  • Chemical Properties White to slightly off-white powder crysta
  • Uses immune modulator
  • Uses Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes
  • Uses Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
  • Definition ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
  • General Description Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.
  • Biochem/physiol Actions Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
  • storage +4°C (desiccate)
  • References [1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
    [2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.
Spermine Preparation Products And Raw materials
Raw materials
Preparation Products
Spermine Suppliers
Global(348)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Hangzhou FandaChem Co.,Ltd.
  • Tel：008657128800458;<br/>+8615858145714
  • Email：FandaChem@Gmail.com
  • Country：China
  • ProdList：3608
  • Advantage：55
Spermine Spectrum
71-44-3, SpermineRelated Search:
  • Elisa Kit-Mouse Elisa Kit
  • co-factor
  • Glutamate
  • Inhibitors
  • Amines
  • Aliphatics
  • 酶与辅酶
  • 抗衰老
  • 抑制剂
  • 分子砌块
  • 天然产物
  • 中间体产品
  • 大化工产品
  • 有机产品
  • 对照品
  • 精细化工品
  • 黄金产品
  • 化工材料
  • 化工原料
  • 生化试剂-其他化学试剂
  • 化工产品-有机化工
  • 有机化工原料
  • 化学试剂
  • 小分子抑制剂，天然产物
  • 其他生化试剂
  • 小分子抑制剂
  • 生化试剂
  • DNA &amp; RNA Purification
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Nitric Oxide Metabolism
  • Molecular Biology
  • Substrate Analogs
  • Reagents
  • Plant Biotechnology
  • Plant Molecular Biology
  • Peptide Analysis and Characterization
  • Nucleic Acid Purification
  • NOS Inhibitors
  • Crystallization
  • Crystallization and Renaturation Screening Kit Components
  • Enzyme Inhibitors
  • Cell Signaling Enzymes
  • BioChemika Ultra
  • Application Index
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • C10H26N4
  • H2NCNHNHCH24NH2
  • NH2CH23NHCH24NHCH23NH2
  • H2NCH23NHCH23NH2
  • 77-44-3
  • 精胺检测标准品
  • GERONTINE|||MUSCULAMINE|||精胺|||4,9-DIAZA-1,12-DODECANEDIAMINE|||NSC 268508|||NEURIDINE
  • 【标准品对照品】SPERMINE 精胺
  • 小鼠和精胺ELISA试剂盒
  • SPERMINE 精胺 SIGMA

Home

My