ChemicalBook > CAS DataBase List > 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Structure
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
  • CAS No.394-32-1
  • Chemical Name:1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
  • CBNumber:CB6267638
  • Molecular Formula:C8H7FO2
  • Formula Weight:154.14
  • MOL File:394-32-1.mol
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Property
  • Melting point 56-58 °C(lit.)
  • Boiling point 65-66 °C8 mm Hg(lit.)
  • Density 1.1850 (estimate)
  • Flash point 65-66°C/8mm
  • storage temp. Inert atmosphere,Room Temperature
  • pka 10.17±0.18(Predicted)
  • form powder to crystal
  • color White to Gray to Brown
  • Water Solubility Soluble 0.68 G/L
  • BRN 2359087
  • CAS DataBase Reference 394-32-1(CAS DataBase Reference)
  • FDA UNII UE6FHC9K7M
  • NIST Chemistry Reference 5-Fluoro-2-hydroxyacetophenone(394-32-1)
  • UNSPSC Code 12352100
  • NACRES NA.22
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: 247170
  • Product name : 5′-Fluoro-2′-hydroxyacetophenone
  • Purity: 98%
  • Packaging: 1G
  • Price: ₹1558.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 247170
  • Product name : 5′-Fluoro-2′-hydroxyacetophenone
  • Purity: 98%
  • Packaging: 5G
  • Price: ₹6863.05
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: F0318
  • Product name : 5'-Fluoro-2'-hydroxyacetophenone
  • Purity: min. 98.0 %
  • Packaging: 5G
  • Price: ₹6400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: F0318
  • Product name : 5'-Fluoro-2'-hydroxyacetophenone
  • Purity: min. 98.0 %
  • Packaging: 25G
  • Price: ₹7200
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A15614-14
  • Product name : 5'-Fluoro-2'-hydroxyacetophenone, 98%
  • Purity: 
  • Packaging: 25g
  • Price: ₹15993
  • Updated: 2022/05/26
  • Buy: Buy

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Usage,Production

  • Chemical Properties light yellow to beige-brown crystals 
  • Uses 5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:
    • 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
    • 3-hydroxy and 3-methoxyflavones
    • 3-hydroxy and 3-methoxy 2-styrylchromones
  • Definition ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.
  • Preparation Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).
  • General Description 5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.
  • Synthesis The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
    Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
    Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
    Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Suppliers
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Spectrum
394-32-1, 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanoneRelated Search:
  • 1
  • Carbonyl Compounds
  • Alcohols and Derivatives
  • Benzenes
  • (intermediate of nebivolol)
  • ketone
  • Aromatic Acetophenones & Derivatives (substituted)
  • Ketones
  • Carbonyl Compounds
  • C7 to C8
  • Phenols
  • Fluorine Compounds
  • Adehydes, Acetals & Ketones
  • Acetophenone series
  • Other Fluorinated Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Organic Building Blocks
  • Fluorinated Building Blocks
  • Chemical Synthesis
  • C7-C8
  • C7 to C8
  • Building Blocks
  • Aryl Fluorinated Building Blocks
  • 医用原料
  • 高端化学
  • 化学试剂-有机试剂
  • 分子砌块
  • 化学试剂
  • 普通
  • 中间体
  • 苯乙酮系列
  • 其他化学试剂
  • 细胞生物学
  • 苯环类中间体
  • 杂环化合物
  • 羰基化合物
  • 醇类及衍生物
  • 苯环类
  • 医药中间体
  • 细胞信号和神经生物学
  • 医药原料
  • Organic Building Blocks
  • Ketones
  • KETONE
  • C7 to C8
  • Carbonyl Compounds
  • Building Blocks
  • 5'-氟-2'-羟基苯乙酮
  • 5-氟-2-羟基苯乙酮2'-羟基-5'-氟苯乙酮,5'-氟-2'-羟基苯乙酮,2-乙酰基-4-氟苯酚
  • 2-乙酰基-4-氟苯酚
  • 2'-羟基-5'-氟苯乙酮
  • 5'-氟-2'-羟基苯乙酮,98%
  • 1-(5-氟-2-羟基苯基)乙酮
  • 1-(5-氟-2-羟苯基)乙酮
  • 5-氟-2-羟基苯乙酮
  • 394-32-1
  • 5'-Fluoro-2'-hydroxyacetophenone
  • 1-(5-fluro-2-hydroxyphenyl)ethanone

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