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RO-32-0432

RO-32-0432 Structure
RO-32-0432
  • CAS No.151342-35-7
  • Chemical Name:RO-32-0432
  • CBNumber:CB6262512
  • Molecular Formula:C28H28N4O2
  • Formula Weight:452.55
  • MOL File:151342-35-7.mol
RO-32-0432 Property
  • Boiling point 712.2±60.0 °C(Predicted)
  • Density 1.32±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility DMSO: soluble
  • form solid
  • pka 7.91±0.60(Predicted)
  • color orange
  • UNSPSC Code 12352111
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • HS Code  :3822000000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

RO-32-0432 Chemical Properties,Usage,Production

  • Uses Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.
  • Biological Activity Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .
RO-32-0432 Preparation Products And Raw materials
Raw materials
Preparation Products
RO-32-0432 Suppliers
Global(59)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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RO-32-0432 Spectrum
151342-35-7, RO-32-0432Related Search:
  • inhibitor
  • 抑制剂
  • C28H28N4O2ClH
  • C28H28N4O2HCl
  • 化合物 RO 32-0432 HYDROCHLORIDE
  • 化合物 T23244
  • (S)-3-[8-[(二甲基氨基)甲基]-6,7,8,9-四氢吡啶并[1,2-A]吲哚-10-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮
  • 151342-35-7
  • (S)-Ro 32-0432 free base
  • Ro 32 0432 hydrochloride,Ro 320432 hydrochloride
  • 1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-
  • BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
  • Ro 31-0432
  • 3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride
  • 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride
  • Bisindoylmaleimide XI: 2-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide
  • 1H-Pyrrol-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropy rido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-, (S)-
  • (S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • 2-(8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL)-3-(1-METHYLINDOL-3-YL)MALEIMIDE HYDROCHLORIDE
  • 2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL
  • BISINDOYLMALEIMIDE XI HYDROCHLORIDE
  • BISINDOLYLMALEIMIDE XL, HCL
  • BISINDOLYLMALEIMIDE XI HYDROCHLORIDE
  • BISINDOLYLMALEIMIDE XI, HCL
  • RO 32-0432 HYDROCHLORIDE
  • RO 32-0432 HCL
  • RO-32-0432

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