17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Description

Prostaglandin F_2α (PGF_2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.^1,2,3 17-trifluoromethylphenyl trinor PGF_2α is an analog of PGF_2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF_2α methyl ester is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF_2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

Uses

17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester is an analog of PGF2α[1].

References

1. Samuelsson, B., Goldyne, M., Granstrm, E., et al. Prostaglandins and thromboxanes Annu. Rev. Biochem. 47,997-1029(1978).
2. Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology Am. J. Obstet. Gynecol. 107(7),1111-1130(1970).
3. Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes J. Reprod. Fertil. 103(1),55-61(1995).