ChemicalBook > CAS DataBase List > 2'-deoxy-2'-fluoro-2'-C-methyluridine

2'-deoxy-2'-fluoro-2'-C-methyluridine

2'-deoxy-2'-fluoro-2'-C-methyluridine Structure
2'-deoxy-2'-fluoro-2'-C-methyluridine
  • CAS No.863329-66-2
  • Chemical Name:2'-deoxy-2'-fluoro-2'-C-methyluridine
  • CBNumber:CB62525846
  • Molecular Formula:C10H13FN2O5
  • Formula Weight:260.22
  • MOL File:863329-66-2.mol
2'-deoxy-2'-fluoro-2'-C-methyluridine Property
  • Melting point 237-238℃
  • Density 1.55
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMSO (Slightly), Methanol (Slightly, Heated)
  • pka 9.39±0.10(Predicted)
  • form Solid
  • color White to Light Beige
  • FDA UNII 44V7045CXS
Safety
  • HS Code  :2934.99.4400
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H319-H335-H315
  • Precautionary statements P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
2'-deoxy-2'-fluoro-2'-C-methyluridine Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: D4823
  • Product name : PSI-6206
  • Purity: 
  • Packaging: 200MG
  • Price: ₹5900
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4823
  • Product name : PSI-6206
  • Purity: 
  • Packaging: 1G
  • Price: ₹16500
  • Updated: 2022/05/26
  • Buy: Buy

2'-deoxy-2'-fluoro-2'-C-methyluridine Chemical Properties,Usage,Production

  • Description (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine / PSI-6206 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) RNA polymerase.
  • Uses RO 2433 is the deaminated metabolite of β-D-2''-Deoxy-2''-fluoro-2''-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.
  • Biological Activity psi-6206 (as known as ro-2433 or gs-331007), β-d-2’-deoxy-2’-fluoro-2’-c-methyluridine, is the deaminated derivative of psi-6130, β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine, which is a potent inhibitor of hepatitis c virus (hcv) replication in the subgenomic hcv reolicon system. psi-6206, itself, does not shown any inhibitory activity towards hcv replication in the hcv subgenomic replicon system. however, the its triphosphate form, ro2433-tp, is a potent inhibitor of rna synthesis by hcv polymerase, which inhibits both the rna sysnthesis activity of hcv replicase (ic50 = 1.19 um) and the rna synthesis activity of the recombinant hcv con1 ns58 on a heteropolymeric rna template derived from the 3’-end of the negative strand of the hcv genome (ic50 = 0.52 um and ki = 0.141 um).han ma, wen-rong jiang, nicole robledo, vincent leveque, samir ali, teresa lara-jamie, mohammad masjedizadeh, david b. smith, nick cammack, klaus klumpp, and julian symons. characterization of the metabolic ctivation of hepatitis c virus nucleoside inhibitor β-d-2’-deoxy-2’-fluoro-2’-c-methylcytidine (psi-6130) and identification of a novel active 5’-triphosphate species. the journal of biological chemistry 2007; 282(41): 29812-29820
  • target HCV
2'-deoxy-2'-fluoro-2'-C-methyluridine Preparation Products And Raw materials
Raw materials
Preparation Products
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2'-deoxy-2'-fluoro-2'-C-methyluridine Spectrum
863329-66-2, 2'-deoxy-2'-fluoro-2'-C-methyluridineRelated Search:
  • Inhibitors
  • apis
  • Inhibitor
  • Sofosbuvir intermediate
  • 化学试剂
  • 抑制剂
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  • 医药原料
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  • 索氟布韦 中间体
  • 芳烃衍生物
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  • 中间体
  • 原料药
  • 索非中间体
  • 原料
  • 医药中间体
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • 8663329-66-2
  • 索弗布韦中间体SF-3
  • 化合物PSI6206,10 MM DMSO 溶液
  • 化合物 PSI6206
  • 2'-脱氧-2'-氟-2'-C-甲基尿苷(2'-F-2'-ME-DU)
  • (2''R)-2''-脱氧-2''-氟-2''-甲基脲苷
  • 索非司布韦国际药典杂质D
  • 1-[(2R,3R,4R,5R)-3-氟-4-羟基-5-(羟甲基)-3-甲基噁戊环-2-基]-1,2,3,4-四氢嘧啶-2,4-二酮
  • SOFOSBUVIR 代谢物 GS331007
  • 索非布韦INT
  • (SF-IM-P)
  • 2'-DEOXY-2'-FLUORO-2'-C -METHYLURIDINE; 1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHYLTETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,4H)-DIONE
  • (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷(2'R)-2'-脱氧-2'-氟-2'-甲基脲苷
  • 索非布韦代谢物
  • 索菲布韦中间体/(2'R)-2'-脱氧-2'-氟-2'-甲基脲苷
  • 索非布韦代谢产物GS331007
  • SOFOSBUVIR代谢产物GS331007
  • 索非布韦IMP-11
  • 2'-脱氧-2'-氟-2'-C-甲基尿苷
  • (2'R)-2'-去氧-2'-氟-2'-甲基尿苷
  • (2R)-2-脱氧-2-氟-2-甲基-尿苷(索非布韦中间体)
  • 索非布韦核苷衍生物
  • 1-((2R,3R,4R,5R)-3-氟-4-羟基-5-(羟甲基)-3-甲基四氢呋喃-2-基)嘧啶-2,4-(1H,3H)-二酮
  • 2'-脱氧-2'-氟-2'-甲基脲苷
  • 索非布韦中间体3
  • 索非布韦中间体
  • 索氟布韦 中间体 SF-1
  • (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷
  • (2'R)-2'-脱氧-2'-氟-2'-M乙YL-尿苷
  • (2'R)-2'-脱氧-2'-氟-2'-
  • (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷(索氟布韦中间体)
  • 索氟布韦中间体(2'R)-2'-脱氧-2'-氟-2'-甲基脲苷
  • (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷(索非布韦中间体)

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