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ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE Structure
ISOCORYDINE HYDROCHLORIDE
  • CAS No.475-67-2
  • Chemical Name:ISOCORYDINE HYDROCHLORIDE
  • CBNumber:CB6238999
  • Molecular Formula:C20H23NO4
  • Formula Weight:341.4
  • MOL File:475-67-2.mol
ISOCORYDINE HYDROCHLORIDE Property
  • Melting point 216-220 °C(lit.)
  • alpha D20 +195° (chloroform)
  • Boiling point 477.03°C (rough estimate)
  • Density 1.2064 (rough estimate)
  • refractive index 1.5614 (estimate)
  • solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • form Cryst.
  • pka 9.41±0.20(Predicted)
  • color White to off-white
  • FDA UNII 3B5E87JEOX
Safety
  • WGK Germany  :3
  • RTECS  :CE1057950
  • Toxicity :LD50 intraperitoneal in mouse: 104mg/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ISOCORYDINE HYDROCHLORIDE Chemical Properties,Usage,Production

  • Description Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.
  • Uses Isocorydine is an alkaloid inhibitor of eukaryotic kinases.
  • Uses sedative, cholinergic
  • Uses Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.
  • Definition ChEBI: Isocorydine is an aporphine alkaloid.
  • in vivo

    Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth[1].

    Animal Model:Female nude mice[1]
    Dosage:0.4 mg/ml
    Administration:Injected intraperitoneally every 2 days for 2 weeks
    Result:Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC.
  • target Dopamine Receptor | P450 (e.g. CYP17)
  • References See Isocorydine
ISOCORYDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ISOCORYDINE HYDROCHLORIDE Suppliers
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ISOCORYDINE HYDROCHLORIDE Spectrum
475-67-2, ISOCORYDINE HYDROCHLORIDERelated Search:
  • Alkaloids
  • Miscellaneous Natural Products
  • Inhibitors
  • 生物碱类
  • 抑制剂
  • 杂质对照品
  • 药靶配体
  • 生物碱
  • 精细化工
  • 对照品-中药对照品
  • 标准品 -中药标准品
  • 中药对照品
  • 标准品
  • 小分子抑制剂
  • 植物提取物
  • 小分子抑制剂，天然产物
  • Heterocyclic Building Blocks
  • Forensic and Veterinary Standards
  • Chromatography
  • Drug Standards
  • Others
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • 异紫堇定碱/生物碱类
  • ARTABOTRIN|||S-ISOCORYDINE(+)|||异紫堇定|||LUTEANIN|||UZOKORIDIN|||(+)-ISOCORYNOLINE
  • 异紫堇碱
  • 盐酸异紫堇定
  • 异紫堇定碱
  • 异紫堇定碱,右旋异紫堇定
  • 右旋异紫堇定
  • 475-67-2
  • Artabotrin|||S-Isocorydine(+)|||Luteanin|||Uzokoridin|||(+)-Isocorynoline
  • 4H-Dibenzo[de,g]quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)-
  • Uzokoridin
  • (+)-Isocorynoline hydrochloride
  • (+)-isocorynoline
  • Aporphin-11-ol, 1,2,10-trimethoxy-
  • Aids-138466
  • Aids138466
  • 1,2,10-Trimethoxy-6-methyl-5,6,6A,7-tetrahydro-4H-dibenzo[de,G]quinolin-11-ol
  • S-ISOCORYDINE (+)
  • Isocorydine
  • [6aS,(+)]-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol
  • (6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol
  • 11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE HYDROCHLORIDE
  • 11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE
  • (6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol
  • ISOCORYDINE HYDROCHLORIDE
  • (+)-ISOCORYDINE HYDROCHLORIDE
  • ISOCORYDINE HCL, (+)-
  • (+)-ISOCORYDINE HCL
  • D-ISOCORYDINE HYDROCHLORIDE
  • luteanine(aporphine)
  • luteanin
  • l-(+)-isocorydine
  • d-isocorydine

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