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BW A868C

BW A868C Structure
BW A868C
  • CAS No.118675-50-6
  • Chemical Name:BW A868C
  • CBNumber:CB6236339
  • Molecular Formula:C25H37N3O5
  • Formula Weight:459.58
  • MOL File:118675-50-6.mol
BW A868C Property
  • Boiling point 638.1±65.0 °C(Predicted)
  • Density 1.24±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility DMSO: >5 mg/mL, soluble
  • form solid
  • pka 4.77±0.10(Predicted)
  • color colorless
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H319-H350
  • Precautionary statements P201-P202-P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P308+P313-P337+P313-P370+P378-P403+P235-P405-P501
BW A868C Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: B9180
  • Product name : BW A868C
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹73068.75
  • Updated: 2022/06/14
  • Buy: Buy

BW A868C Chemical Properties,Usage,Production

  • Uses BW A868C is a hydantoin compound structurally related to the DP agonist BW245C.
  • Definition ChEBI: BW A868C is an imidazolidine-2,4-dione.
  • Biological Activity bw a868c is a novel, selective and potent competitive antagonist of prostaglandin d2 (pgd2) [1].prostaglandin d2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system [2]. prostaglandin d2 is critical for the development of allergic diseases such as asthma.
  • in vitro in glycerol-lysed human platelets, bw245c activated adenylate cyclase in a biphasic manner. bw a868c showed no effect on carbacyclin, iloprost, prostacyclin, pge1 and pge2 at a concentration 1,000 fold that of its kb against pgd2 and bw245c [1]. bw a868c showed no effect on human tp, ip, ep1, ep2, and fp receptors. the ki value for bw a868c is approximately 1.7 nm[1] .in isolated rings of rabbit saphenous vein (rbsv) pre-contracted with 40 mm kcl, bw245c caused concentration-dependent relaxations with an ec50 of 38 nm [3].
  • IC 50 DP2
  • References [1] giles h, leff p, bolofo m l, et al. the classification of prostaglandin dp‐receptors in platelets and vasculature using bw a868c, a novel, selective and potent competitive antagonist[j]. british journal of pharmacology, 1989, 96(2): 291-300.
    [2] shimizu t, mizuno n, amano t, et al. prostaglandin d2, a neuromodulator[j]. proceedings of the national academy of sciences, 1979, 76(12): 6231-6234.
    [3] lydford s j, mckechnie k c w, leff p. interaction of bw a868c, a prostanoid dp-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein[j]. prostaglandins, 1996, 52(2): 125-139.
BW A868C Preparation Products And Raw materials
Raw materials
Preparation Products
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BW A868C Spectrum
118675-50-6, BW A868CRelated Search:
  • 抑制剂
  • 试剂盒-细胞分析试剂盒
  • C25H37N3O5
  • 化合物 BW A868C
  • 化合物 T21869
  • 3-[(2-环己基-2-羟乙基)氨基]-2,5-二氧代-1-(苯甲基)-4-咪唑啶庚酸
  • 118675-50-6
  • 4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-
  • 3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid
  • 7-[3-[(2-CYCLOHEXYL-2-HYDROXYETHYL)AMINO]-2,5-DIOXO-1-(PHENYLMETHYL)-4-IMIDAZOLIDINYL]HEPTANOIC ACID
  • (+/-)-3-BENZYL-5-(6-CARBOXYHEXYL)-1-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)HYDANTOIN
  • 3-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)-2,5-DIOXO-1-BENZYL-4-IMIDAZOLIDINEHEPTANOIC ACID
  • BW A868C

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