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AJMALINE

AJMALINE Structure
AJMALINE
  • CAS No.4360-12-7
  • Chemical Name:AJMALINE
  • CBNumber:CB6235145
  • Molecular Formula:C20H26N2O2
  • Formula Weight:326.44
  • MOL File:4360-12-7.mol
AJMALINE Property
  • Melting point 189°C
  • alpha D18 +131° (c = 0.4 in chloroform); D20 +144° (c = 0.8 in chloroform)
  • Boiling point 464.47°C (rough estimate)
  • Density 1.1117 (rough estimate)
  • refractive index 1.6800 (estimate)
  • storage temp. 2-8°C
  • solubility Chloroform (Slightly), DMSO (Slightly)
  • form Solid
  • pka pKa 8.2 (Uncertain)
  • color White
  • optical activity +14420 (CHCl3)
  • Water Solubility 489.7mg/L(30 ºC)
  • Merck 13,194
  • LogP 1.810
  • EWG's Food Scores 1
  • FDA UNII 1PON08459R
  • ATC code C01BA05
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :25-20/21/22
  • Safety Statements  :13-45-36
  • RIDADR  :1544
  • RTECS  :AX8050000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • Toxicity :LD50 oral in rat: 360mg/kg
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H312-H332
  • Precautionary statements P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312
AJMALINE Price More Price(2)
  • Brand: ottokemi
  • Product number:  A 1550
  • Product name : Ajmaline
  • Purity: 98%
  • Packaging: 1gm
  • Price: ₹10602
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: SRL
  • Product number: 52821
  • Product name : Ajmaline pure, 98%
  • Purity: 
  • Packaging: 1Gms
  • Price: ₹3380
  • Updated: 2022/05/26
  • Buy: Buy

AJMALINE Chemical Properties,Usage,Production

  • Description Rauwolfia (Luo Fu Mu) is derived from the plants Rauvolfia verticillata (Lour.) Baill. and R. yunnanensis Tsiang, and the root is usually used as its medicinal part. R. verticillata (Lour.) Baill. var. hainanensis Tsiang and R. vomitoria Afzel. ex Spreng have been also used as traditional Chinese herb.
    Rauwolfia is one of the important traditional herbs in southern China. Its scope of treatment includes cold, fever, sore throat, headache, and dizziness caused by hypertension, abdominal pain and diarrhea, scabies, and so on. Rauwolfia is also used to treat insomniac dizziness, bruises, sprains, and venomous snake bites in folk.
    In the “Flora of China,” 135 species of Rauwolfia were recorded, mostly distributed in the tropics and subtropics, a few in the temperate regions. There are nine species, four varieties, and three cultivated species in China.
  • Chemical Properties White Solid
  • Physical properties Appearance: white or yellowish crystal powder. Melting point: its anhydride is 205– 207?°C. Optical rotation: +144° (chloroform). Solubility: well soluble in organic solvents, such as methanol, ethanol, etc., and slightly soluble in water. Storage temperature: 2–8?°C.
  • Originator Ajmaline ,Solvay Pharma
  • History Since 1930s, abundant studies have been focused on the Rauwolfia plants. So far, a total of 91 alkaloids were separated from Rauwolfia, and the identification of the chemical structures was obtained, including 2 non-indole alkaloids (thebaine and papaverine) and 89 indole alkaloids . In accordance with the basic framework, indole alkaloids can be divided into seven classes, such as the ajmaline class, the
  • Uses For use as an antiarrhythmic agent.
  • Uses An antiarrhythmic agent isolated from Rauwolfia serpentina.
  • Definition ChEBI: A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.
  • Manufacturing Process Ajmaline isolated from Rauwolfia sp. roots: Rauwolfia serpentine Benth., Rauwolfia vomitoria Afr., Rauwolfia canescens L.
    Threshed roots of Rauwolfia canescens L. extracted with 5% solution of acetic acid at room temperature for 24 h. Then extract was decanted to flask. This extract was alkalified with ammonia (alkaloid salts were converted to alkaloid bases). The obtained thus method solution was extracted with chloroform 3 or more times. Then chloroform extract was chromatographed on column through Al2O3 sorbent. After chromatography ajmalin was obtained, which had melting point at 205°C (recyrstallization from methanol).
  • Therapeutic Function Antiarrhythmic
  • Pharmacology Anti-arrhythmic R. serpentina (She Geng Mu) is the first anti-arrhythmic herbal medicine in the psychiatry history. Ajmaline has a potent anti-arrhythmic effect for treating atrial and ventricular arrhythmias and also has a good effect on the treatment of Wolff-Parkinson-White syndrome. Ajmaline plays a main role in decreasing the permeability of sodium ion on the myocardial cell membrane by moderately inhibiting the sodium channel. The electrophysiological effect of ajmaline is similar to that of quinidine, but it is stronger than quinidine.
    In addition, ajmaline has a mild anti-sympathetic effect. It affects sympathetic nerve endings to release more sodium, dilate the coronary artery, relax vascular smooth muscle, and then decrease blood pressure. Therefore, it is suitable for clinical treatment of atrial and ventricular premature beats, pre-excitation syndrome with supraventricular tachycardia, but not suitable for the treatment of paroxysmal
    atrial fibrillation and sinus tachycardia.
  • Clinical Use Ajmaline has the anti-arrhythmic effects for the treatment of atrial or ventricular extrasystoles, paroxysmal supraventricular or ventricular tachycardia, and paroxysmal atrial fibrillation. The lethal dose for human ranged from 100 to 500?mg/kg.
  • Side effects Side effects include disturbances of the central nervous system and intrahepatic cholestasis.
  • target Potassium Channel
  • Purification Methods Ajmaline crystallises from MeOH or EtOAc containing a little H2O to give the trihydrate m 158-160o. This loses 1H2O at 110o and all H2O at 150o. [Beilstein 23 III/IV 3212.]
  • References Le Gall., Ann. ph arm. franc., 18,817 (1960)
AJMALINE Preparation Products And Raw materials
Raw materials
Preparation Products
AJMALINE Suppliers
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AJMALINE Spectrum
4360-12-7, AJMALINERelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Alkaloids
  • 抑制剂
  • 药靶配体
  • 化学原料
  • 试剂
  • 化学试剂
  • 标准品
  • 对照品
  • 标准品 -中药标准品
  • 原料药
  • 医药原料
  • 医用原料
  • 医用原料
  • 医药原料
  • 植物提取
  • 医药化工类
  • 降血压药物
  • 植物提取物
  • 医药原料药
  • C20H26N2O2
  • 4036-12-7
  • 阿义马林,10 MM DMSO 溶液
  • PERFEMIKER]阿吗灵,98%
  • (5AR,6S,8R,9S,10R,11R,11AS,12AR,13R)-9-乙基-5-甲基-5A,6,8,9,10,11,11A,12-八氢-5H-6,10:11,12A-二甲桥吲哚并[3,2-B]喹啉-8,13-二醇
  • 阿义马林 阿马林 西萝芙木碱
  • 阿义马林/阿马林/阿马义林/阿义吗啉/
  • 阿义吗啉/阿马林
  • 阿义吗啉 降血压药物
  • 西萝芙木碱
  • 缓脉灵
  • 阿义马林
  • 阿马灵
  • 阿义吗啉
  • 阿吗灵
  • 蘿芙鹼
  • 阿嗎靈鹼
  • 阿马林(阿义吗啉)
  • 阿马灵,阿义马林
  • 4360-12-7
  • Ajmaline, 10 mM in DMSO
  • Carisoprodol Impurity 10
  • (5aR,6S,8R,9S,10R,11R,11aS,12aR,13R)-9-Ethyl-5-methyl-5a,6,8,9,10,11,11a,12-octahydro-5H-6,10:11,12a-dimethanoindolo[3,2-b]quinolizine-8,13-diol
  • Ajmalan-17,21-diol, (17R,21α)-
  • Ajmaline (6CI, 7CI, 8CI)
  • 5H-6,10:11,12a-Dimethanoindolo[3,2-b]quinolizine, ajmalan-17,21-diol deriv.
  • Ajmaline pure, 98%
  • AJMALINE USP/EP/BP
  • AJMALINE(P)
  • NSC 15627
  • (17R,21α-AjMalan-17,21-diol
  • AJMALINE(RG)
  • AJMALINE:AJMALAN-17,21-DIOL,(17R,21)-,
  • Ajamline Fr P.
  • RAUWOLFINE
  • Takycor Azapromazine
  • Takycor

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