Synthesis
The general procedure for the synthesis of 2-(trifluoromethyl)benzamide from 2-(trifluoromethyl)benzoyl chloride is as follows: 2-(trifluoromethyl)benzoyl chloride (50 g) was added to a reaction vessel with isopropanol (400 g) and ammonia was passed into it. The reaction mixture was stirred at a temperature range of -10°C to 0°C for 3.5 hours to facilitate the reaction. Upon completion of the reaction, ammonium chloride precipitated as a precipitate and the reaction mixture was separated by filtration to obtain a filtrate. Subsequently, the filtrate was concentrated to obtain the final target product 2-(trifluoromethyl)benzamide (compound of formula I). The yield of this synthesis step was 90% and the purity of the product (as determined by HPLC) was 99%.
References
[1] Patent: WO2015/193911, 2015, A1. Location in patent: Page/Page column 7
[2] Patent: US2008/86008, 2008, A1. Location in patent: Page/Page column 10
[3] Synthetic Communications, 2010, vol. 40, # 23, p. 3538 - 3543
[4] Journal of the American Chemical Society, 1947, vol. 69, p. 2352
[5] Agricultural and Biological Chemistry, 1991, vol. 55, # 3, p. 763 - 768
