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Lufenuron

CAS No.103055-07-8
Chemical Name:Lufenuron
CBNumber:CB6229074
Molecular Formula:C17H8Cl2F8N2O3
Formula Weight:511.15
MOL File:103055-07-8.mol

Lufenuron Property

Melting point 174.1°
Density 1.631±0.06 g/cm3(Predicted)
vapor pressure <0.4 x10 -3 Pa (25 °C)
Flash point 170 °C
storage temp. 0-6°C
solubility 100mg/L in organic solvents at 20 ℃
form Solid
Water Solubility <0.06 mg l^-1(25 °C)
pka 8.49±0.46(Predicted)
color Off-white to light yellow
JECFA Number 85
BRN 8398291
InChIKey PWPJGUXAGUPAHP-UHFFFAOYSA-N
LogP 5.12 at 25℃
CAS DataBase Reference 103055-07-8(CAS DataBase Reference)
EWG's Food Scores 1-2
FDA UNII 1R754M4918
Pesticides Freedom of Information Act (FOIA) Lufenuron
EPA Substance Registry System Benzamide, N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluoro- (103055-07-8)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi;N,N,Xi
Risk Statements :43-50/53
Safety Statements :2-24-37-60-61
RIDADR :3077
WGK Germany :2
HazardClass :9
PackingGroup :III
HS Code :29242990
Toxicity :LD50 in rats (mg/kg): >2000 orally; LC50 in rats (mg/m3): >2350 (Buholzer)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H317-H410
Precautionary statements P261-P272-P273-P280-P302+P352-P333+P313

Lufenuron Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: PHR3031
Product name : Lufenuron
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: ₹12394.63
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 31662
Product name : Lufenuron
Purity: PESTANAL?, analytical standard
Packaging: 100MG
Price: ₹11355.43
Updated: 2022/06/14
Buy: Buy

Lufenuron Chemical Properties,Usage,Production

Description Lufenuron is an insect development inhibitor of the benzoylphenyl urea class. It demonstrates activity against fleas that have fed on treated cats and dogs and become exposed to lufenuron in the host’s blood. Lufenuron also has activity by virtue of its presence in adult flea feces, leading to its ingestion by flea larvae. Both activities result in the production of eggs that are unable to hatch, causing significant reductions in flea larvae populations. The lipophilicity of lufenuron leads to its deposition in adipose tissues of animals from where it is slowly released into the bloodstream. This permits effective blood concentrations to be maintained throughout the recommended oral dosing interval of 1 month.
Uses Lufenuron is used for the control of Lepidoptera and Coleoptera larvae on cotton, maize and vegetables, and of citrus whitefly and rust mites on citrus fruit. It is also used to control fleas on pets and cockroaches in houses.
Definition ChEBI: Lufenuron is a benzoylurea insecticide, a dichlorobenzene, a N-acylurea, an aromatic ether and an organofluorine compound.
Flammability and Explosibility Not classified
Pharmacology Antiparasitic. Lufenuron is a benzoylurea insecticide. This class of insecticides was previously used on fruits to decrease damage by insects. Lufenuron (Program) has been used for prevention of flea infections in dogs and cats because it inhibits chitin synthesis. For this use, it has been given to dogs at a dose of 10 mg/kg every 30 days and to cats at a dose of 30 mg/kg every 30 days. It may also have some inhibition on fungal cell membranes because it inhibits the cell wall of fungi, which contain chitin, and other complex polysaccharides. Because of this property on fungal cell membranes, there has been interest in using lufenuron to treat dermatophytes in small animals. However, proven efficacy has been controversial. Well-controlled studies have not confirmed consistent efficacy for treating dermatophytes in animals.
Veterinary Drugs and Treatments Lufenuron is approved for use in dogs and cats 6 weeks of age and older for the control of flea populations. The combination product of lufenuron and milbemycin (Sentinel?) is indicated for use in puppies and dogs 4 weeks and older for prevention and control flea populations, prevention of heartworm disease, control of adult hookworms, and the removal and control of adult roundworms and whipworms.
Lufeneron showed initial promise as a treatment for fungal infections, but the early enthusiasm has dampened considerably as efficacy appears doubtful.
Metabolic pathway Only limited information is available in the open literature on the metabolism of lufenuron.
Degradation Lufenuron is less stable at alkaline pH than under acidic conditions. The DT₅₀ at 25 °C is 160 days at pH 5,70 days at pH 7 and 32 days at pH 9 (PM).
Mode of action Lufenuron has no systemic or translaminar effect. It is persistent with a transovarial effect. It may reduce the egg-Iaying rate or hinder the hatching process of embryos.