Description
Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (K
d = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.
References
[1] YIN LI. Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: Differential interactions of these antimitotic agents with brain and fungal tubulins[J]. Biochemical and biophysical research communications, 1992, 187 2: Pages 722-729. DOI:
10.1016/0006-291x(92)91255-o[2] JUBINA B VENGHATERI. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site.[J]. PLoS ONE, 2013: e75182. DOI:
10.1371/journal.pone.0075182[3] K SUWANBORIRUX. Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes.[J]. Experientia, 1990, 46 1: 117-120. DOI:
10.1007/bf01955435[4] K OOTSU. Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro.[J]. Cancer research, 1980, 40 5: 1707-1717.
