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(S)-1-Boc-3-hydroxypiperidine

Uses
(S)-1-Boc-3-hydroxypiperidine Structure
(S)-1-Boc-3-hydroxypiperidine
  • CAS No.143900-44-1
  • Chemical Name:(S)-1-Boc-3-hydroxypiperidine
  • CBNumber:CB6197360
  • Molecular Formula:C10H19NO3
  • Formula Weight:201.26
  • MOL File:143900-44-1.mol
(S)-1-Boc-3-hydroxypiperidine Property
  • Melting point 34-40 °C
  • Boiling point 292.3±33.0 °C(Predicted)
  • Density 1.107±0.06 g/cm3(Predicted)
  • Flash point 110 °C
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • solubility Soluble in methanol.
  • pka 14.74±0.20(Predicted)
  • form Powder or Crystalline Powder
  • color White to tan
  • optical activity [α]22/D +10.0°, c = 1 in chloroform
  • InChI InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
  • InChIKey UIJXHKXIOCDSEB-QMMMGPOBSA-N
  • SMILES N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
  • CAS DataBase Reference 143900-44-1(CAS DataBase Reference)
  • UNSPSC Code 12352005
  • NACRES NA.22
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
(S)-1-Boc-3-hydroxypiperidine Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: 687367
  • Product name : (S)-1-Boc-3-hydroxypiperidine
  • Purity: 97%
  • Packaging: 1G
  • Price: ₹6570.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-H52771-06
  • Product name : (S)-1-Boc-3-hydroxypiperidine, 97%
  • Purity: 
  • Packaging: 5g
  • Price: ₹7799
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: B4446
  • Product name : (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
  • Purity: min. 98.0 %
  • Packaging: 1G
  • Price: ₹2600
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: B4446
  • Product name : (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
  • Purity: min. 98.0 %
  • Packaging: 5G
  • Price: ₹8800
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-H52771-03
  • Product name : (S)-1-Boc-3-hydroxypiperidine, 97%
  • Purity: 
  • Packaging: 1g
  • Price: ₹7459
  • Updated: 2022/05/26
  • Buy: Buy

(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Usage,Production

  • Uses (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
  • Description (S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.
  • Chemical Properties White powder
  • Uses A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
  • Uses (S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.
(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-Boc-3-hydroxypiperidine Suppliers
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