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STATIL

STATIL Structure
STATIL
  • CAS No.72702-95-5
  • Chemical Name:STATIL
  • CBNumber:CB6193847
  • Molecular Formula:C17H12BrFN2O3
  • Formula Weight:391.19
  • MOL File:72702-95-5.mol
STATIL Property
  • Melting point 184-186℃ (DEC.)
  • Density 1.60
  • storage temp. Store at RT
  • solubility DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
  • form A crystalline solid
  • color White to off-white
  • FDA UNII 2CV0A5G64E
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

STATIL Chemical Properties,Usage,Production

  • Description Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.
  • Uses Inhibitor (aldose reductase).
  • Uses Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth
  • Definition ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.
  • Biological Activity Potent aldose reductase inhibitor.
  • in vivo

    Ponalrestat (ICI 128436; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition[3].

    Animal Model:Adult female Sprague-Dawley rats[3]
    Dosage:10, 50 mg/kg
    Administration:Orally; daily; 8 weeks
    Result:Reduced sorbitol accumulation.
STATIL Preparation Products And Raw materials
Raw materials
Preparation Products
STATIL Suppliers
Global(97)Suppliers
  • Supplier：
    career henan chemical co
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    TargetMol Chemicals Inc.
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  • Supplier：
    InvivoChem
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  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
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STATIL Spectrum
72702-95-5, STATILRelated Search:
  • Inhibitors
  • 抑制剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C17H12BrFN2O3
  • 泊那司他,10 MM DMSO 溶液
  • 2-(3-(4-溴-2-氟苄基)-4-氧代-3,4-二氢酞嗪-1-基)乙酸
  • 波来瑞斯 100MG
  • 泊那司他
  • 波来瑞斯
  • 72702-95-5
  • Ponalrestat - Bio-X ?
  • Ponalrestat, 10 mM in DMSO
  • ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1
  • Ponalrestat (MK-538
  • Ponalrestat
  • [3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID
  • STATIL
  • Ponalrestat Statil
  • 2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
  • MK-538
  • ICI-plc
  • ICI-128436
  • 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
  • 3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL)

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