Uses
Z-Phe-Leu-Glu-pNA is a chromogenic substrate for glutamyl endopeptidases. Z-Phe-Leu-Glu-pNA has been used as a synthetic substrate in the study of proteolytic enzymes, including trypsin treatment, subtilisin and chymotrypsin. Z-Phe-Leu-Glu-pNA plays an important role in hormone disorders such as prostate cancer and breast cancer[1][2].
References
[1] Wei Ye, et al. Characterization of the glutamate-specific endopeptidase fromBacillus licheniformisexpressed inEscherichia coli. J Biotechnol. 2013 Oct 10;168(1):40-5. DOI:
10.1016/j.jbiotec.2013.08.009[2] Wei Ye, et al. A new strategy for recovery of two peptides without Glu employing glutamate-specific endopeptidase from Bacillus licheniformis. Enzyme Microb Technol. 2014 Jan 10:54:25-31. DOI:
10.1016/j.enzmictec.2013.09.013
