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N-METHYLNICOTINAMIDE

CAS No.114-33-0
Chemical Name:N-METHYLNICOTINAMIDE
CBNumber:CB6151285
Molecular Formula:C7H8N2O
Formula Weight:136.15
MOL File:114-33-0.mol

N-METHYLNICOTINAMIDE Property

Melting point 102-105 °C(lit.)
Boiling point 250.42°C (rough estimate)
Density 1.1778 (rough estimate)
refractive index 1.5769 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 13.97±0.46(Predicted)
color White to Off-White
CAS DataBase Reference 114-33-0(CAS DataBase Reference)
FDA UNII X3I82S5L8I

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :3
HS Code :2933.39.9200

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

N-METHYLNICOTINAMIDE Price More Price(2)

Brand: TCI Chemicals (India)
Product number: M0374
Product name : N-Methylnicotinamide
Purity: min. 98.0 %
Packaging: 10G
Price: ₹5300
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: M0374
Product name : N-Methylnicotinamide
Purity: min. 98.0 %
Packaging: 25G
Price: ₹8600
Updated: 2022/05/26
Buy: Buy

N-METHYLNICOTINAMIDE Chemical Properties,Usage,Production

Chemical Properties white to light yellow-beige crystalline powder
Uses N-Methylnicotinamide is a metabolite of Nicotinamide (N407750), which is a water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH. N-Methylnicotinamide is commonly found in the human urine and is used as a biomarker to study diseases such as liver cirrhosis and type 2 diabetes.
Definition ChEBI: A pyridinecarboxamide that is nicotinamide in which one of the amide hydrogens is substituted by a methyl group.

in vivo

N-Methylnicotinamide (3-30 mg/kg, i.v., 10 min before the induction of arterial thrombosis) decreases the arterial thrombus weight, collagen induced platelet aggregation and decreases PAI-1 antigen and activity in plasma without changing t-PA activity in 2K-1C hypertensive rats^[1].
N-Methylnicotinamide (30-300 mg/kg, mixed in the diet, daily for 31 days) significantly increases the liver weight, the content of NAD and total nicotinamide in liver and the content of NAD in blood in rats^[3].

Animal Model:	2K-1C hypertensive rats^[1]
Dosage:	3-30 mg/kg
Administration:	i.v., 10 min before the induction of arterial thrombosis
Result:	Resulted in a dose-dependent decrease of arterial thrombus weight, decreased PAI-1 antigen and activity in plasma in dose-dependent manner, whereas it did not change t-PA activity, decreased collagen induced platelet aggregation in dose-dependent manner.

Animal Model:	Weanling male rats^[3]
Dosage:	30-300 mg/kg
Administration:	mixed in the diet, daily for 31 days
Result:	Significantly increased the liver weight, statistically significantly the content of NAD and total nicotinamide in liver and the content of NAD in blood in rats.