ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound SESELIN

SESELIN

Product NameSESELIN
CAS523-59-1
CBNumberCB61444407
MFC14H12O3
MW228.24
MDL NumberMFCD01018179
MOL File523-59-1.mol

Chemical Properties

Melting point:	119-124 °C
Boiling point:	403.0±45.0 °C(Predicted)
Density	1.351 g/cm3(Temp: 18 °C)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	A solid
color	White to off-white
InChI	1S/C14H12O3/c1-14(2)8-7-10-11(17-14)5-3-9-4-6-12(15)16-13(9)10/h3-8H,1-2H3
InChIKey	QUVCQYQEIOLHFZ-UHFFFAOYSA-N
SMILES	[o]1c2c(ccc3c2C=CC(O3)(C)C)cc[c]1=O

Safety

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

SESELIN Chemical Properties,Usage,Production

Uses

Seselin is a coumarin compound that can be isolated from the root bark of the Citropsis articulata plant. Studies show that Seselin might exhibit potential antimalarial activity and that its derivatives may exhibit antithrombotic activity.

Definition

ChEBI: A natural product found in Citropsis articulata.

Biological Activity

Seselin is an anti-inflammatory, anti-parasitic and antifungal pyrancoumarin found in anise and other plants. It appears th at seselin targets Jak2 to block the proinflammatory phenotype of macrophages in models of sepsis. Seselin down-regulates levels of proinflammatory factors and activity of STAT1 and p65 in models of sepsis.

in vivo

Seselin (0.5-40.5 mg/kg; s.c.; once) shows peripheral anti-inflammatory and antinociceptive activities in mice^[2].
Seselin (3-30 mg/kg; i.g.; once) ameliorates sepsis induced by caecal ligation and puncture in mice^[3].

Animal Model:	Male Swiss mice^[2]
Dosage:	0.5, 4.5 or 40.5 mg/kg
Administration:	Subcutaneous injection; once
Result:	Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.

Animal Model:	C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model^[3]
Dosage:	3, 10 and 30 mg/kg
Administration:	Intragastric administration, once
Result:	Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.

SESELIN Suppliers

Supplier	Tel	Email	ProdList	Advantage
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +86-18080483897	sales@biopurify.com	4616	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	3861	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	32430	58
Nantong HI-FUTURE Biology Co., Ltd.	+86-18051384581	sales@chemhifuture.com	3122	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	38999	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	49854	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	info@chemextension.com	42052	58
Mensura Group Limited	18780014153	1058503172@qq.com	2900	58
Gihi Chemicals Co., Limited	+86-0571-86217390 +86-18058761490	info@gihichem.com	995	58
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	2376	60

SESELIN Spectrum

523-59-1(SESELIN) Related Search

Send Inquriy