ChemicalBook > CAS DataBase List > 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE

CAS No.335165-68-9
Chemical Name:3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
CBNumber:CB6143286
Molecular Formula:C19H21Br2N3O
Formula Weight:467.2
MOL File:335165-68-9.mol

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Property

Boiling point 388.1±42.0 °C(Predicted)
Density 1.71±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility ≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
form solid
pka 14.48±0.20(Predicted)
color White

Hazard and Precautionary Statements (GHS)

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.
Biological Activity Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC 50 = 0.52 μ M). Suggested to inhibit Bax channel formation/activity.
in vitro bax channel blocker, a 3,6-dibromocarbazole derivative, was observed to inhibit cytochrome c releasing from mitochondria by bax channel modulation. the monohydroxy analogue bax channel blocker remained the unprecedented inhibition of bax-induced cytochrome c release at 10 μm. the ic50 value of bax channel blocker was determined to be 0.52 μm, indicating that bax channel blocker was a bax channel inhibitor as hypothesized. moreover, in the liposome assay, bax channel blocker showing significant inhibition (>65%) of cytochrome c release at 10 μm also demonstrated sub-micromolar ic50 value [1].
IC 50 0.52 μm in bax assay
References [1] bombrun a,gerber p,casi g,terradillos o,antonsson b,halazy s. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via bax channel modulation. j med chem.2003 oct 9;46(21):4365-8.

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Spectrum

335165-68-9, 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDERelated Search:

Apoptosis Inhibitors
Caspases/Apoptosis
抑制剂
药靶配体
C19H21Br2N3O2HCl
335165-69-9
化合物BAI1,10 MM DMSO 溶液
化合物BAI1
3,6-二溴吲哚-ALPHA-(1-哌嗪甲基)-9H-咔唑-9-乙醇双盐酸盐
1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇
335165-68-9
BAI1, 10 mM in DMSO
Inhibitor,mitochondrial,cell,inhibit,BAI1,effector,BAI 1,critical,BAX,death,BAI-1,Bcl-2 Family,pathway,Apoptosis
BAX CHANNEL BLOCKER
"(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"
BAI1 (Bax channel blocker)
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
)-3-(piperazin-1-yL
9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-
1-(3,6-Dibromo-9H-carbazoL
Bax channel blocker(BAI-1)
Bax channel blocke
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
Baxchannelblocker2HCl