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territrem A

territrem A Structure
territrem A
  • CAS No.70407-19-1
  • Chemical Name:territrem A
  • CBNumber:CB61359936
  • Molecular Formula:C28H30O9
  • Formula Weight:510.536
  • MOL File:70407-19-1.mol
territrem A Property
  • storage temp. Store at -20°C
  • solubility DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
  • form A solid
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

territrem A Chemical Properties,Usage,Production

  • Description Territrem A is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 24 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.31 mg/kg, and has an LD50 value of 17.6 mg/kg.
  • Uses Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.
  • References Territrems, tremorgenic mycotoxins of Aspergillus terreus. Ling K.L. et al., Appl. Env. Microbiol. 1979, 37, 355.
    Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea. Dowd P.F. et al., Entomol. Exp. Appl. 1992, 65, 57.
    Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. Jen-Wei Chen J-W. et al., J. Biol. Chem. 1999, 274, 34916.
territrem A Preparation Products And Raw materials
Raw materials
Preparation Products
territrem A Suppliers
Global(23)Suppliers
  • Supplier： TargetMol Chemicals Inc.
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territrem A Spectrum
70407-19-1, territrem ARelated Search:
  • 抑制剂
  • 土雷姆A
  • 化合物 TERRITREM A
  • 70407-19-1
  • Territrem A（95%）
  • 4H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6a,12b-tetramethyl-, (4aR,6aR,12aS,12bS)-
  • PubChem ID: 115079
  • TERRITREM A(RG)
  • (4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-9-(7-methoxy-1,3-benzodioxol-5-yl)-4,4,6aα,12bα-tetramethyl-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione
  • territrem A

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