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(R)-(-)-3-Pyrrolidinol hydrochloride

(R)-(-)-3-Pyrrolidinol hydrochloride Structure
(R)-(-)-3-Pyrrolidinol hydrochloride
  • CAS No.104706-47-0
  • Chemical Name:(R)-(-)-3-Pyrrolidinol hydrochloride
  • CBNumber:CB6125385
  • Molecular Formula:C4H10ClNO
  • Formula Weight:123.58
  • MOL File:104706-47-0.mol
(R)-(-)-3-Pyrrolidinol hydrochloride Property
  • Melting point 104-107 °C(lit.)
  • alpha -7.6°(20/D, c=3,5, CH3OH)
  • refractive index -7.8 ° (C=3.5, MeOH)
  • storage temp. Inert atmosphere,Room Temperature
  • solubility Soluble in DMSO.
  • form Solid
  • color Pale Brown
  • optical activity [α]20/D 7.6°, c = 3.5 in methanol
  • BRN 4450078
  • InChI InChI=1/C4H9NO.ClH/c6-4-1-2-5-3-4;/h4-6H,1-3H2;1H/t4-;/s3
  • InChIKey QPMSJEFZULFYTB-PGMHMLKASA-N
  • SMILES [C@H]1(O)CNCC1.Cl |&1:0,r|
  • CAS DataBase Reference 104706-47-0(CAS DataBase Reference)
  • UNSPSC Code 12352005
  • NACRES NA.22
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
(R)-(-)-3-Pyrrolidinol hydrochloride Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: 430722
  • Product name : (R)-3-Pyrrolidinol hydrochloride
  • Purity: 98%
  • Packaging: 10G
  • Price: ₹14070
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: P1140
  • Product name : (R)-(-)-3-Pyrrolidinol Hydrochloride
  • Purity: 
  • Packaging: 5G
  • Price: ₹9500
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: P1140
  • Product name : (R)-(-)-3-Pyrrolidinol Hydrochloride
  • Purity: 
  • Packaging: 25G
  • Price: ₹29500
  • Updated: 2022/05/26
  • Buy: Buy

(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties,Usage,Production

  • Chemical Properties Llight brown crystalline
  • Uses (R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize:
    • Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1.
    • Pyrrolidinol based ionic liquids.
    • Optically active 2-tritylpyrrolidine based organocatalysts.

  • Uses (R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.
  • Uses (R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.
  • Purification Methods The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials
Raw materials
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(R)-(-)-3-Pyrrolidinol hydrochloride Spectrum
104706-47-0, (R)-(-)-3-Pyrrolidinol hydrochlorideRelated Search:
  • 11
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