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sordarin sodium salt

CAS No.463356-00-5
Chemical Name:sordarin sodium salt
CBNumber:CB61216297
Molecular Formula:C27H39O8.Na
Formula Weight:514.587
MOL File:463356-00-5.mol

sordarin sodium salt Property

storage temp. -20°C
solubility H2O: soluble ≤10mg/mL
form solid
color White to off-white
biological source Sordaria araneosa
Water Solubility H2O: soluble ≤10mg/mL
UNSPSC Code 51111800
NACRES NA.77

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

sordarin sodium salt Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: S1442
Product name : Sordarin sodium salt
Purity: from Sordaria araneosa, ≥98% (HPLC), solid
Packaging: 5MG
Price: ₹49567.68
Updated: 2022/06/14
Buy: Buy

sordarin sodium salt Chemical Properties,Usage,Production

Description Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa. It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC₅₀ = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC₅₀s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC₅₀ = >100 μg/ml). It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).
Uses Sordarin Sodium Salt is a selective fungal EF-2 inhibitor.
Biochem/physiol Actions Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C.?albicans, C.?glabrata, and C.?neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.