Dimethyl cyclohexane-1,2-dicarboxylate

Synthesis

131-11-3

1687-29-2

The general procedure for the synthesis of methyl cis-1,2-cyclohexanedicarboxylate from dimethyl phthalate is as follows: the hydrogenation reaction was carried out in a 25 mL stainless steel autoclave with a PTFE liner. In typical operation, 20 mg of catalyst and 61 mg (0.5 mmol) of dimethyl phthalate were dispersed in 5 mL of deionized water. After sealing the autoclave, the air in the autoclave was replaced with hydrogen and pressurized to 2.5 MPa. Under magnetic stirring (1000 rpm), the reaction mixture was heated to 110 °C and maintained until the reaction was completed. At the end of the reaction, it was cooled to room temperature, the reaction mixture was extracted with ethyl acetate and separated by centrifugation to remove the solid catalyst. The recovered solid catalyst was washed sequentially with ethyl acetate, ethanol and deionized water. The filtrate was analyzed by a gas chromatograph (HP5890, USA) equipped with a 30 m HP-5 capillary column and a flame ionization detector (FID). All products were confirmed by gas chromatography-mass spectrometry (Agilent 6890).

References