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Apoptolidin

Apoptolidin Property

Melting point 128-130°
alpha 21D -5.2° (c = 1.0 in methanol)
Boiling point 1108.9±65.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
Flash point 87℃
storage temp. -20°C
solubility Soluble in DMSO, DMF, ethanol, or methanol.
pka 11.71±0.70(Predicted)
form DMSO solution
color White
biological source Amycolatopsis sp.
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months.
FDA UNII SAO6WVQ23I
UNSPSC Code 12352200
NACRES NA.77

Safety

NFPA 704:

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319
Precautionary statements P264-P270-P280-P301+P312-P330-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501

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Apoptolidin Chemical Properties,Usage,Production

Description Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1?Is believed to act via inhibition of F0F1-ATPase2?but correlation studies indicate that a second mechanism may be the actual mode of action3.? Cell permeable.
Uses Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
References 1) Kim et al. (1997), Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.; J. Antibiot. (Tokyo), 50 628 2) Salomon et al. (2001), Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase; Chem. Biol., 8 71 3) Wender et al. (2006), Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues; Org. Lett., 8 589

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Apoptolidin Spectrum

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Apoptolidin A Ready Made Solution
Apoptolidin