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Triethyl citrate

Toxicity Description References

Triethyl citrate

CAS No.77-93-0
Chemical Name:Triethyl citrate
CBNumber:CB5854363
Molecular Formula:C12H20O7
Formula Weight:276.28
MOL File:77-93-0.mol

Triethyl citrate Property

Melting point -55 °C
Boiling point 235 °C/150 mmHg (lit.)
Density 1.14 g/mL at 25 °C (lit.)
vapor density 9.7 (vs air)
Pour Point -46
vapor pressure 1 mm Hg ( 107 °C)
FEMA 3083 | TRIETHYL CITRATE
refractive index n20/D 1.442(lit.)
Flash point >230 °F
storage temp. Store below +30°C.
solubility H2O: soluble
pka 11.57±0.29(Predicted)
form Liquid
color Clear
Odor odorless
biological source synthetic
Viscosity 35.2cp (25C)
Water Solubility 5.7 g/100 mL (25 ºC)
FreezingPoint -55℃
Merck 14,2326
JECFA Number 629
BRN 1801199
InChIKey DOOTYTYQINUNNV-UHFFFAOYSA-N
LogP 1.267 (est)
FDA 21 CFR 184.1911; 175.300; 175.320; 181.27
Substances Added to Food (formerly EAFUS) TRIETHYL CITRATE
SCOGS (Select Committee on GRAS Substances) Triethyl citrate
CAS DataBase Reference 77-93-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 8Z96QXD6UM
NIST Chemistry Reference Ethyl citrate(77-93-0)
EPA Substance Registry System Triethyl citrate (77-93-0)
UNSPSC Code 85151701
NACRES NA.41

Safety

Hazard Codes :Xn
Risk Statements :20
Safety Statements :24/25-45
WGK Germany :1
RTECS :GE8050000
TSCA :Yes
HS Code :2918 15 00
Hazardous Substances Data :77-93-0(Hazardous Substances Data)
Toxicity :LD50 orally in Rabbit: > 3200 mg/kg LD50 dermal Rabbit > 5000 mg/kg

NFPA 704:

	1
		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

Triethyl citrate Price More Price(20)

Brand: Sigma-Aldrich(India)
Product number: W308307
Product name : Triethyl citrate
Purity: ≥99%, FCC, FG
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Brand: Sigma-Aldrich(India)
Product number: W308307
Product name : Triethyl citrate
Purity: ≥99%, FCC, FG
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Brand: Sigma-Aldrich(India)
Product number: W308307
Product name : Triethyl citrate
Purity: ≥99%, FCC, FG
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Brand: Sigma-Aldrich(India)
Product number: W308307
Product name : Triethyl citrate
Purity: ≥99%, FCC, FG
Packaging: 25KG
Price: ₹72148.63
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Brand: Sigma-Aldrich(India)
Product number: W308302
Product name : Triethyl citrate
Purity: natural, ≥99%, FG
Packaging: 1SAMPLE-K
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Triethyl citrate Chemical Properties,Usage,Production

Toxicity AD10~20mg/kg (FAO/WHO, 2001). GRAS (FDA, §182.1911, 2000). LD505900 mg/kg (rat, oral).
Description Triethyl citrate is the triester of citric acid and ethyl alcohol.
Triethyl citrate is used as a flavoring agent in foods, as a high boiling solvent and plasticizer for vinyl resins and cellulose acetates, as a plasticizer in the pharmaceutical industry for coating. Triethyl citrate is used as a natural active ingredient and flavor component with excellent deodorizing and skin care properties in cosmetic and personal care products. Triethyl citrate is also used as a plasticizer and humectant for cigarette filters. Furthermore, triethyl citrate is used s a food additive for stabilizing foams, specifically as a whipping enhancer for organic egg whites during processing.
References [1] RH Dave (2016) Overview of pharmaceutical excipients used in tablets and capsules, Drug Topics (online). Advanstar.
[2] http://www.who.int/en/
[3] http://www.in-cosmetics.com
[4] http://www.chemicalland21.com
[5] https://www.ams.usda.gov/sites/default/files/media/Triethyl%20Citrate%20report%202014.pdf
Chemical Properties Triethyl citrate is a clear, viscous, odorless, and practically colorless, hygroscopic liquid.
Chemical Properties Colorless, mobile liquid; bitter taste. Solubility in water 6.5 g/100 cc; solubility in oil 0.8 g/100 cc. Combustible.
Chemical Properties Triethyl citrate is odorless, but has a bitter taste.
Occurrence Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white wine.
Uses Triethyl Citrate, is a colorless, odorless liquid used as a food additive to stabilize foams, especially as whipping aid for egg white. It is also used in pharmaceutical coatings and plastics. This compound is a contaminant of emerging concern (CECs).
Uses Pharmaceutic aid (plasticizer).
Uses Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu- ble in water. it is found in lemon drinks.
Production Methods Triethyl citrate is prepared by the esterification of citric acid and ethanol in the presence of a catalyst.
Definition ChEBI: Triethyl citrate is a carbonyl compound.
Preparation By esterification of ethyl alcohol with citric acid.
General Description Triethyl citrate is a safe direct food additive.
Pharmaceutical Applications Triethyl citrate and the related esters acetyltriethyl citrate, tributyl citrate, and acetyltributyl citrate are used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent.
Safety Profile Moderately toxic by intraperitoneal route. Mildly toxic by ingestion and inhalation. Combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and CITRIC ACID.
Safety Triethyl citrate is used in oral pharmaceutical formulations and as a direct food additive. It is generally regarded as a nontoxic and nonirritant material. However, ingestion of large quantities may be harmful.
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg
storage Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.
Incompatibilities Triethyl citrate is incompatible with strong alkalis and oxidizing materials.
Toxics Screening Level The final ITSL for triethyl citrate is 290 μg/m3 (annual average).
Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.