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o-Toluic acid

CAS No.118-90-1
Chemical Name:o-Toluic acid
CBNumber:CB5852905
Molecular Formula:C8H8O2
Formula Weight:136.15
MOL File:118-90-1.mol

o-Toluic acid Property

Melting point 102-104 °C (lit.)
Boiling point 258-259 °C (lit.)
Density 1.062 g/mL at 25 °C (lit.)
refractive index 1.512
Flash point 148 °C
storage temp. Sealed in dry,Room Temperature
solubility 1.2g/l
pka 3.91(at 25℃)
form Needle-Like Crystalline Solid
color White to slightly yellow
Specific Gravity 1.062
PH 3.1 (H2O, 20℃)(saturated aqueous solution)
Water Solubility <0.1 g/100 mL at 19 ºC
Merck 14,9535
BRN 1072103
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey ZWLPBLYKEWSWPD-UHFFFAOYSA-N
CAS DataBase Reference 118-90-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 9NR3033Y0U
NIST Chemistry Reference Benzoic acid, 2-methyl-(118-90-1)
EPA Substance Registry System o-Toluic acid (118-90-1)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi,Xn
Risk Statements :36/37/38-22
Safety Statements :26-36-22
WGK Germany :3
RTECS :XU1400000
TSCA :Yes
HS Code :29163900

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

o-Toluic acid Price More Price(12)

Brand: Sigma-Aldrich(India)
Product number: T36404
Product name : o-Toluic acid
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Brand: Sigma-Aldrich(India)
Product number: T36404
Product name : o-Toluic acid
Purity: 99%
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Brand: ALFA India
Product number: ALF-A13856-30
Product name : o-Toluic acid, 98+%
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Brand: TCI Chemicals (India)
Product number: T0292
Product name : o-Toluic Acid
Purity:
Packaging: 25G
Price: ₹1800
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Brand: ALFA India
Product number: ALF-A13856-0I
Product name : o-Toluic acid, 98+%
Purity:
Packaging: 5000g
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o-Toluic acid Chemical Properties,Usage,Production

Chemical Properties White crystals. Slightly soluble in water; soluble in alcohol and chloroform. Combustible.
Uses Bacteriostat.
Uses o-Toluic acid is part of a group of Benzoic acid (B203900) derivatives that possess inhibitory activity against mushroom tyrosinases. o-Toluic acid is also used as a reagent to synthesize halogen-substituted benzoic acids (such as 2,4-Dichlorobenzoic acid [D431955]), which have potential muscle stimulating effects.
Definition ChEBI: A methylbenzoic acid that is benzoic acid substituted by a methyl group at position 2.
Synthesis Reference(s) Organic Syntheses, Coll. Vol. 2, p. 588, 1943
The Journal of Organic Chemistry, 25, p. 616, 1960 DOI: 10.1021/jo01074a035
Tetrahedron Letters, 22, p. 1013, 1981 DOI: 10.1016/S0040-4039(01)82853-7
Air & Water Reactions Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.
Reactivity Profile o-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in o-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. o-Toluic acid is incompatible with strong oxidizers.
Fire Hazard Flash point data for o-Toluic acid are not available. o-Toluic acid is probably combustible. Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Purification Methods Crystallise the acid from *benzene (2.5mL/g) and dry in air. The S-benzylisothiuronium salt has m 146o (from aqueous EtOH). [Beilstein 9 IV 1697.]