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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Structure
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
  • CAS No.86030-08-2
  • Chemical Name:4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
  • CBNumber:CB5783210
  • Molecular Formula:C12H8ClNO4S
  • Formula Weight:297.71
  • MOL File:86030-08-2.mol
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Property
  • Melting point 115 °C
  • Boiling point 471.2±35.0 °C(Predicted)
  • Density 1.476±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,Room Temperature
  • solubility Soluble in DMSO (30 mg/ml)
  • form solid
  • color White to off-white
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H314
  • Precautionary statements P260-P280-P301+P330+P331

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties,Usage,Production

  • Description BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5
  • Uses BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.
  • storage Store at +4°C
  • References Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072 Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554 Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539 Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41 Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Suppliers
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    TargetMol Chemicals Inc.
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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Spectrum
86030-08-2, 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENERelated Search:
  • 抑制剂
  • 药靶配体
  • 标准品
  • 细胞生物学试剂
  • 化合物BTB1,10 MM DMSO 溶液
  • BTB1,KIF18A抑制剂
  • 化合物BTB1
  • KIF18A抑制剂(BTB-1)
  • 4-氯-2-硝基-1-(苯基磺酰基)苯
  • 86030-08-2
  • BTB-1, 10 mM in DMSO
  • Inhibitor,BTB-1,inhibit,BTB1,Microtubule/Tubulin
  • Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)-
  • NSC156750
  • 1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid
  • BTB 1; BTB1
  • BTB 1 - NSC 156750 | NSC 658180
  • BTB-1
  • 4-Chloro-2-nitrodiphenyl sulphone
  • 1-Benzenesulfonyl-4-chloro-2-nitro-benzene
  • 4-chloro-2-nitro-1-(phenylsulphonyl)benzene
  • 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
  • 4-CHLORO-2-NITRODIPHENYL SULFONE
  • LABOTEST-BB LT01147747

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