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ITE

ITE Structure
ITE
  • CAS No.448906-42-1
  • Chemical Name:ITE
  • CBNumber:CB5754713
  • Molecular Formula:C14H10N2O3S
  • Formula Weight:286.31
  • MOL File:448906-42-1.mol
ITE Property
  • Melting point 234 - 236°C
  • Boiling point 520.4±48.0 °C(Predicted)
  • Density 1.427±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: 30 mg/mL, soluble
  • pka 14.38±0.30(Predicted)
  • form solid
  • color Off-White to Light Yellow
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H319-H315
  • Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

ITE Chemical Properties,Usage,Production

  • Uses ITE is an endogenous AHR ligand that parenterally or orally induces FoxP3+ Treg that suppress exprimental autoimmune encephalomyelitis. ITE promotes the induction of active immunology tolerance and identifies nontoxic endogenous AHR ligands.
  • Definition ChEBI: 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester is an indolyl carboxylic acid.
  • Biological Activity Endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); K i = 3 nM for binding to murine AHR. Transactivates DRE-containing reporter gene constructs in Hepa1c1c7 cells ~ 5-fold more potently than β -naphthoflavone. Active in vivo .
  • in vivo

    ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice[2].

  • storage Store at RT
ITE Preparation Products And Raw materials
Raw materials
Preparation Products
ITE Suppliers
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ITE Spectrum
448906-42-1, ITERelated Search:
  • 抑制剂
  • 药靶配体
  • 化工原料
  • 细胞生物学试剂
  • C14H10N2O3S
  • 化合物ITE,10 MM DMSO 溶液
  • ITE,内源性芳烃受体(AHR)激动剂
  • 甲基 2-(1H-吲哚-3-羰基)-1,3-噻唑-4-甲酸基酯
  • 化合物ITE
  • 芳香烃受体(AHR)激动剂(ITE)
  • 2-(1H-吲哚-3-基羰基)-4-噻唑羧酸甲酯
  • 448906-42-1
  • ITE - Bio-X ?
  • ITE, 10 mM in DMSO
  • ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR
  • 4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
  • ARYL HYDROCARBON RECEPTOR LIGAND
  • methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
  • Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate
  • 2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester
  • 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID
  • 2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER
  • ITE

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