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Lomefloxacin hydrochloride

Lomefloxacin hydrochloride Structure
Lomefloxacin hydrochloride
  • CAS No.98079-52-8
  • Chemical Name:Lomefloxacin hydrochloride
  • CBNumber:CB5723616
  • Molecular Formula:C17H20ClF2N3O3
  • Formula Weight:387.81
  • MOL File:98079-52-8.mol
Lomefloxacin hydrochloride Property
  • Melting point 290-3000C
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility 1 M NaOH: soluble50mg/mL
  • form powder to crystal
  • color white to off-white
  • biological source synthetic
  • Merck 14,5562
  • CAS DataBase Reference 98079-52-8(CAS DataBase Reference)
  • FDA UNII 9VC7S3ZXXB
  • UNSPSC Code 51282927
  • NACRES NA.85
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :3
  • RTECS  :VB1997500
  • HS Code  :29339900
  • NFPA 704:
    0
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H317
  • Precautionary statements P261-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P501
Lomefloxacin hydrochloride Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: L2906
  • Product name : Lomefloxacin hydrochloride
  • Purity: 
  • Packaging: 1G
  • Price: ₹5748.08
  • Updated: 2022/06/14
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  • Brand: Sigma-Aldrich(India)
  • Product number: L2906
  • Product name : Lomefloxacin hydrochloride
  • Purity: 
  • Packaging: 10G
  • Price: ₹32583.25
  • Updated: 2022/06/14
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  • Brand: TCI Chemicals (India)
  • Product number: L0216
  • Product name : Lomefloxacin Hydrochloride
  • Purity: 
  • Packaging: 5G
  • Price: ₹6500
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: SRL
  • Product number: 52737
  • Product name : Lomefloxacin Hydrochloride (LMF), 98.5%
  • Purity: 
  • Packaging: 1Gms
  • Price: ₹1260
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: SRL
  • Product number: 52737
  • Product name : Lomefloxacin Hydrochloride (LMF), 98.5%
  • Purity: 
  • Packaging: 5Gms
  • Price: ₹3260
  • Updated: 2022/05/26
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Lomefloxacin hydrochloride Chemical Properties,Usage,Production

  • Description Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.
  • Description Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
  • Chemical Properties White powder with no smell, bitter taste
  • Originator Foxil,Sarabhai Chemicals,India
  • Uses Fluorinated quinolone antibacterial. DNA gyrase antagonist
  • Definition ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media.
  • Manufacturing Process A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless needles, melting point 239.0-240.5°C.
    By the usual manner the hydrochloride was prepared and recrystallized from water as colorless needles, melting point 290-300°C (decomp.).
  • brand name Maxaquin (Pharmacia).
  • Therapeutic Function Antibacterial
  • References Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
    Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.
Lomefloxacin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Lomefloxacin hydrochloride Spectrum
98079-52-8, Lomefloxacin hydrochlorideRelated Search:
  • Lomefloxacin
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  • Quinolones (Antibiotics for Research and Experimental Use)
  • Biochemistry
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  • Halogenated Heterocycles ,Benzothiazoles
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  • 喹诺酮类药
  • 抗生素
  • 生化试剂
  • 原料药
  • C17H19F2N3O3ClH
  • C17H20ClF2N3O3
  • C17H19F2N3O3HCl
  • 盐酸洛美沙星纯度标准物质
  • 甲醇中盐酸洛美沙星溶液标准物质
  • 甲醇中盐酸洛美沙星溶液
  • 甲醇中盐酸洛美沙星(以洛美沙星计)
  • 甲醇中盐酸美洛沙星溶液标准物质
  • 甲醇/水中盐酸洛美沙星溶液
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  • LOMEFLOXACIN盐酸盐[干冰运输]
  • 盐酸洛美沙星
  • 盐酸氟罗沙星
  • 盐酸洛美沙星/(±)-1-乙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧喹啉-3-羧酸盐酸盐
  • 盐酸洛美沙星(标准品)
  • 盐酸洛美沙星,98%
  • (+/-)-1-乙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧-喹啉-3-羧酸盐酸盐
  • (±)-1-乙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧喹啉-3-羧酸盐酸盐
  • 洛美沙星盐酸盐
  • 98079-52-8
  • C14646000 Lomefloxacin hydrochloride
  • 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride

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