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beta-Cyclodextrin methyl ethers

CAS No.128446-36-6
Chemical Name:beta-Cyclodextrin methyl ethers
CBNumber:CB5696215
Molecular Formula:C54H94O35
Formula Weight:1303.3
MOL File:128446-36-6.mol

beta-Cyclodextrin methyl ethers Property

Melting point 180-182 °C(lit.)
alpha +159°(25℃, c=1, H2O)
Flash point 187 °C
storage temp. room temp
solubility H2O: soluble50mg/mL
form powder
color White to off-white
optical activity [α]25/D +159°, c = 1 in H2O
biological source synthetic (organic)
Water Solubility Soluble in water
InChIKey YZOUYRAONFXZSI-SBHWVFSVSA-N
LogP -2.566 (est)
FDA UNII F9TVU546K5
EPA Substance Registry System .beta.-Cyclodextrin, methyl ethers (128446-36-6)
Absorption ≤0.10 at 350-600nm in solution at 10%
≤1.00 at 220-350nm in solution at 10%
UNSPSC Code 12352201
NACRES NA.77

Safety

Safety Statements :22-24/25
WGK Germany :3
TSCA :Yes
HS Code :35051000

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H317-H361
Precautionary statements P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c

beta-Cyclodextrin methyl ethers Price More Price(19)

Brand: Sigma-Aldrich(India)
Product number: C4555
Product name : Methyl-β-cyclodextrin
Purity: powder, BioReagent, suitable for cell culture
Packaging: 1G
Price: ₹5975.4
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: M7439
Product name : Methyl-β-cyclodextrin
Purity:
Packaging: 1G
Price: ₹3929.48
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C4555
Product name : Methyl-β-cyclodextrin
Purity: powder, BioReagent, suitable for cell culture
Packaging: 5G
Price: ₹25427.93
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C4555
Product name : Methyl-β-cyclodextrin
Purity: powder, BioReagent, suitable for cell culture
Packaging: 10G
Price: ₹43278.35
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 779873
Product name : Methyl-β-cyclodextrin
Purity: Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, ≥98.0% cyclodextrin basis
Packaging: 100G
Price: ₹49513.55
Updated: 2022/06/14
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beta-Cyclodextrin methyl ethers Chemical Properties,Usage,Production

Description Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Chemical Properties White powder
Uses Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Uses Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.
Uses substrate for laminarinase and other glucanases
General Description Methyl-β-cyclodextrin is a small cyclic heptasaccharide.
Biochem/physiol Actions Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.