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OLVANIL

CAS No.58493-49-5
Chemical Name:OLVANIL
CBNumber:CB5461006
Molecular Formula:C26H43NO3
Formula Weight:417.62
MOL File:58493-49-5.mol

OLVANIL Property

Melting point 36 °C
Boiling point 596.1±50.0 °C(Predicted)
Density 0.982±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility H₂O: <0.2mg/mL
form powder
pka 9.76±0.20(Predicted)
color white to off-white
Water Solubility H2O: <0.2mg/mL
DMSO: 20mg/mL
FDA UNII 4P7KIU7003
UNSPSC Code 51111800
NACRES NA.77

Safety

WGK Germany :3
RTECS :RG2242130

NFPA 704:

	3
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H319
Precautionary statements P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501

OLVANIL Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: O0257
Product name : Olvanil
Purity: powder
Packaging: 10MG
Price: ₹18954.58
Updated: 2022/06/14
Buy: Buy

OLVANIL Chemical Properties,Usage,Production

Description Olvanil is a structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus. It is the amide of vanillylamine and oleic acid. Olvanil acts as an agonist at the vanilloid receptor, VR1, inducing desensitization analgesia in rat and mouse models of pain. Olvanil has complex interactions with the cannabinoid system, in that it potentiates the agonist activity of endogenous cannabinoids by inhibiting the reuptake of arachidonyl ethanolamide (AEA). Olvanil is a more potent reuptake inhibitor than AM404, which is commonly used for this purpose (50% inhibition of reuptake at 10 μM versus 12% for AM404 at the same dose). Olvanil is also a CB₁ agonist, but does not bind to CB₂ receptors or inhibit fatty acid amide hydrolase. The overall activity of olvanil in most models is that of an analgesic, but it is unclear how these effects are mediated by VR1, the CB₁ receptor, or other components of the endogenous pain sensation system.
Uses Analgesic.
Uses Olvanil is a TRPV1 agonist more potent than capsaicin.
Definition ChEBI: N-Vanillyloleamide is a member of methoxybenzenes and a member of phenols.
Biological Activity Potent vanilloid receptor agonist (pEC 50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC 50 = 9 μ M) and may bind to CB 1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
storage Desiccate at -20°C