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ACETYL-DL-CARNITINE HYDROCHLORIDE

CAS No.2504-11-2
Chemical Name:ACETYL-DL-CARNITINE HYDROCHLORIDE
CBNumber:CB5440058
Molecular Formula:C9H18ClNO4
Formula Weight:239.7
MOL File:2504-11-2.mol

ACETYL-DL-CARNITINE HYDROCHLORIDE Property

Melting point 181 - 183°C
storage temp. -20°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
Water Solubility Soluble to 100 mM in water
Stability Hygroscopic
CAS DataBase Reference 2504-11-2(CAS DataBase Reference)
FDA UNII 2WQN168TM5
UNSPSC Code 12352209
NACRES NA.26

Safety

WGK Germany :3
RTECS :BP2979200

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

ACETYL-DL-CARNITINE HYDROCHLORIDE Price More Price(4)

Brand: Sigma-Aldrich
Product number: A1509
Product name : Acetyl-DL-carnitine hydrochloride
Purity:
Packaging: 250MG
Price: ₹8172.88
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: A1509
Product name : Acetyl-DL-carnitine hydrochloride
Purity:
Packaging: 250MG
Price: ₹8172.88
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: A1509
Product name : Acetyl-DL-carnitine hydrochloride
Purity:
Packaging: 1G
Price: ₹26077.43
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: A1509
Product name : Acetyl-DL-carnitine hydrochloride
Purity:
Packaging: 1G
Price: ₹26077.43
Updated: 2022/06/14
Buy: Buy

ACETYL-DL-CARNITINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses (±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
Biological Activity (±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions Weak cholinergic receptor agonist; intermediate in lipid metabolism.
in vivo
In rats, the infusion of 2 mg (±)-Acetylcarnitine chloride decreases blood flow through the hind limb vasculature 50%. (±)-Acetylcarnitine chloride also potentiates the inhibitory effect of adrenaline on the isolated rabbit duodenum^[3].
Purification Methods Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]