ChemicalBook > CAS DataBase List > O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE

O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE

CAS No.2086-26-2
Chemical Name:O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE
CBNumber:CB5431153
Molecular Formula:C7H9ClN2O3
Formula Weight:204.61
MOL File:2086-26-2.mol

O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Property

Melting point 215 °C (dec.)(lit.)
Boiling point 226°C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Sensitive Moisture & Light Sensitive
BRN 3709565
CAS DataBase Reference 2086-26-2(CAS DataBase Reference)
EPA Substance Registry System Hydroxylamine, O-[(4-nitrophenyl)methyl]-, monohydrochloride (2086-26-2)
UNSPSC Code 12352100
NACRES NA.22

Safety

Risk Statements :36/37/38
Safety Statements :22-24/25
WGK Germany :3
RTECS :NC4400050
F :3-8-9
TSCA :Yes
HazardClass :IRRITANT
HS Code :29280000

NFPA 704:

	0
0		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 73200
Product name : O-(4-Nitrobenzyl)hydroxylamine hydrochloride
Purity: ≥98.5% (AT)
Packaging: 1G
Price: ₹7317.7
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 73200
Product name : O-(4-Nitrobenzyl)hydroxylamine hydrochloride
Purity: ≥98.5% (AT)
Packaging: 5G
Price: ₹26640.33
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A5532
Product name : O-4-Nitrobenzylhydroxylamine Hydrochloride [for HPLC Labeling]
Purity:
Packaging: 1G
Price: ₹7200
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A5532
Product name : O-4-Nitrobenzylhydroxylamine Hydrochloride [for HPLC Labeling]
Purity:
Packaging: 5G
Price: ₹15000
Updated: 2022/05/26
Buy: Buy

O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties LIGHT YELLOW POWDER
Uses A strong UV chromophore used in derivatization of reducing sugars for ultraviolet absorption detection in HPLC analyses.
Uses As a strong UV chromophore, O-(4-Nitrobenzyl)hydroxylamine hydrochloride can be used in derivatization of reducing sugars for ultraviolet absorption detection in HPLC analyses.
Preparation To a solution of 25 gm (0.183 mole) of benzohydroxamic acid in 28 ml of ethanol and 10.2 gm (0.184 mole) of potassium hydroxide in 40 ml of water is added a hot solution of 39.4 gm (0.184 mole) of p-nitrobenzyl bromide in ethanol. The mixture is then heated under a reflux condenser for 45 min and cooled. The precipitated crystals are separated and crystallized from ethanol. (No yield reported.) A solution of 15 gm (0.055 mole) of the above o-p-nitrobenzylbenzohy-droxamic acid (p-nitrobenzyl benzohydroxamate) in 125 ml of hot ethanol is heated to reflux for 25 min with 150 ml of cone, hydrochloric acid. To prevent the precipitation of the final product during the work-up, the following steps are carried out rapidly. The clear solution is diluted with 150 ml of water and while still warm benzoic acid and other by-products are separated by extraction with 200 ml of chloroform. The aqueous layer is evaporated to dryness under reduced pressure to afford a crude yield of 10.75 gm (96%). The residue is recrystallized from hot 2 Ν hydrochloric acid and washed in turn with ethanol and with ether to afford a solid, m.p. 217°C.
The free base may be produced by neutralizing the salt with sodium carbonate solution; O-p-nitrobenzylhydroxylamine, m.p. 56°C (recrystallized from petroleum ether). By a similar technique, O-allylhydroxylamine hydrochloride, m.p. 172°C (dec.) was also prepared.

An examination of the product of butylating benzohydroxamic acid showed that a nonacidic fraction and an equal weight of an acidic fraction were readily isolated. The nonacidic fraction contained mainly Ο, Ο '-dibutyl benzohydroxi-mate (b.p. 175-180°C/13 mm Hg) and some aniline (probably formed during the reaction by a Lossen rearrangement). On hydrolysis with eth-anolic hydrochloric acid, the hydroximate produced ethyl benzoate and O-butylhydroxylamine hydrobromide (m.p. 159-161°C; hydrochloride, m.p. 156-157°C).
The acidic fraction contained mainly O-butylbenzohydroxamic acid (butyl benzohydroxamate) which on hydrolysis formed O-butylhydroxylamine hydrochloride and benzoic acid. It has been contended that in this particular work, the presence of an Ν,Ο-dibutylbenzohy-droxamic acid had been overlooked. The major source of O-butylhydroxylamine hydrochloride is from the acidic fraction, although the yield is not particularly high. The initial preparation of the butylated benzohydroxamic acid derivatives has been repeated recently. The analysis of the reaction products by vapor-phase chromatography showed it to contain 43% of O-butylbenzohydroxamic acid (butyl benzohydroxamate), 17% of iV,0-dibutyl-benzohydroxamic acid, and 8% of n-butyl(Z)-0-n-butylbenzohydroximate:

The nature of the remaining 32% of the crude reaction product was not determined. The use of benzohydroxamic acid has been extended to the preparation of a variety of O-substituted hydroxylamines. For example, halocarboxylic acids have been used as alkylating agents to produce α-aminooxy acids of the type, NH20(CH2)„C02H.
A variety of O-benzylhydroxylamines, O-aralkylhydroxylamines, as well as simpler O-substituted hydroxylamines have also been prepared. In some of these preparations, the hydrolysis of the O-substituted benzohydroxamic acid was carried out with hot alcoholic hydrogen chloride. This treatment evidently prevented the O-N cleavage which had been observed during the aqueous hydrolysis of the substituted benzohydroxamic acids.