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alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Structure
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
  • CAS No.3200-06-4
  • Chemical Name:alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
  • CBNumber:CB5426302
  • Molecular Formula:C26H35NO7
  • Formula Weight:473.56
  • MOL File:3200-06-4.mol
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Property
  • Melting point 110-111°
  • Boiling point 574°C (rough estimate)
  • Density 1.2205 (rough estimate)
  • refractive index 1.6000 (estimate)
  • storage temp. Store at -20°C
  • solubility Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone.
  • form Solid
  • color White to off-white
  • FDA UNII 5ADB8D9388
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xn,Xi
  • Risk Statements  :22
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :LU5805000
  • HS Code  :29321900
  • Toxicity :LD50 oral in rat: 711mg/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H312
  • Precautionary statements P264-P270-P280-P301+P312-P302+P352+P312-P362+P364
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: N1391
  • Product name : Nafronyl oxalate salt
  • Purity: analytical standard
  • Packaging: 5G
  • Price: ₹9017.23
  • Updated: 2022/06/14
  • Buy: Buy

alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Chemical Properties,Usage,Production

  • Chemical Properties White solid
  • Originator Dusodril,Roland,W. Germany,1968
  • Uses antineoplastic
  • Manufacturing Process 30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams (0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3. Extraction with ether is carried out after drying over Na2SO4.
    Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity = 40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved while being made tepid in 8 cc of acetone. The cooled solution has added thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'- tetrahydrofuryl isobutyrate, obtained according to the process described above and dissolved in 10 cc of acetone. The solution is brought to boiling point for 15 minutes. After cooling to ambient temperature, it is placed in a refrigerator. Crystallization occurs after 2 hours, the crystals which have formed are separated by centrifuging, and after washing in hexane and drying in vacuo 3.5 grams of white crystals are obtained. After being recrystallized three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the product is analytically pure and has a MP = 110° to 111°C (heating stage).
  • brand name Praxilene (Lipha, S.A., France).
  • Therapeutic Function Vasodilator
  • Biological Activity Vasodilator
  • Clinical Use Vasodilator:
    Peripheral and cerebral vascular disease
  • Metabolism Metabolised by plasma pseudo-cholinesterases to 3 active metabolites.
alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Preparation Products And Raw materials
Raw materials
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alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Spectrum
3200-06-4, alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalateRelated Search:
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  • 3200-06-4
  • Naftidrofuryl oxalate, 10 mM in DMSO
  • 2-Furanpropanoic acid, tetrahydro-a-(1-naphthalenylmethyl)-,2-(diethylamino)ethyl ester, ethanedioate (1:1)
  • 5-hydroxytryptamine Receptor,Inhibitor,Naftidrofuryl oxalate,Serotonin Receptor,Naftidrofuryl,inhibit,5-HT Receptor,Nafronyl
  • alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate USP/EP/BP
  • Nafronyl oxalate salt USP/EP/BP
  • Acid oxalate
  • α-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
  • Nafronyl oxalate salt ,98%
  • Nafronyl oxalate salt ,99%
  • 2-(DiethylaMino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)Methyl)propanoate oxalate
  • Nafronyl oxalate salt ,96%
  • Iridus
  • 2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl esteroxalate (1:1)
  • 2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester oxalate (1:1)
  • 2-Furanpropanoic acid, tetrahydro-.alpha.-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester, ethanedioate (1:1)
  • 2-(Diethylamino)ethyl tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropionate oxalate (1:1)
  • NAFRONYL OXALATE SALT
  • NAFRONYL OXALATE
  • ALPHA-[1-NAPHTHYLMETHYL]-2-TETRAHYDROFURANPROPIONIC ACID DIETHYLAMINOETHYL ESTER OXALATE SALT
  • alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
  • α-(1-naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester
  • Nafronyl acid oxalate
  • CLARANTIN
  • diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate
  • naftidrofuryloxalate
  • ls121
  • hylester,oxalate(1:1)
  • eu-1806
  • 2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionateo

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